人造纳米颗粒治疗脑肿瘤。

IF 2 4区 医学 Q3 ONCOLOGY Oncology Research Pub Date : 2024-12-20 eCollection Date: 2025-01-01 DOI:10.32604/or.2024.053069
Soroush Soleymani, Mohammad Doroudian, Mahdieh Soezi, Ali Beladi, Kiarash Asgari, Aso Mobarakshahi, Aryana Aghaeipour, Ronan Macloughlin
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引用次数: 0

摘要

脑转移瘤和原发性多形性胶质母细胞瘤是最常见和最致命的恶性脑肿瘤。它的中位生存时间通常在诊断后不到一年。治疗这些癌症的主要挑战之一是药物转运到中枢神经系统的效率。血脑屏障与恶性肿瘤的晚期相配合。血脑屏障对向脑肿瘤输送全身药物构成了重大挑战。纳米药物输送系统已经成为有效跨越这一屏障的有前途的工具。此外,智能纳米粒子的发展为癌症的诊断和治疗带来了新的希望。这些纳米颗粒提高了药物递送效率,允许创建靶向和刺激反应的递送方法。本文重点介绍了纳米颗粒和智能纳米颗粒技术在脑癌治疗中的最新进展,探讨了纳米颗粒的开发范围、应用、靶向策略以及增强血脑屏障运输的最新进展。它还讨论了这些创新方法的持续挑战和潜在好处。
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Engendered nanoparticles for treatment of brain tumors.

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system. The blood-brain barrier is cooperating with advanced stages of malignancy. The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors. Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier. Additionally, the development of smart nanoparticles brings new hope for cancer diagnosis and treatment. These nanoparticles improve drug delivery efficiency, allowing for the creation of targeted and stimuli-responsive delivery methods. This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment, exploring the range of nanoparticles under development, their applications, targeting strategies, and the latest progress in enhancing transport across the blood-brain barrier. It also addresses the ongoing challenges and potential benefits of these innovative approaches.

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来源期刊
Oncology Research
Oncology Research 医学-肿瘤学
CiteScore
4.40
自引率
0.00%
发文量
56
审稿时长
3 months
期刊介绍: Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.
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