鞭毛藻对肝癌大鼠癌性线粒体的毒性作用。

Q2 Medicine Asian Pacific Journal of Cancer Prevention Pub Date : 2024-12-01 DOI:10.31557/APJCP.2024.25.12.4273

Enayatollah Seydi, Mahsa Barzegar, Melika Nazemi, Zhaleh Mohsenifar, Nazanin Shahbazi, Abbas Jafarian-Dehkordi, Jalal Pourahmad

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引用次数: 0

摘要

背景与目的：肝细胞癌（HCC）是世界范围内公认的主要公共卫生问题和致命恶性肿瘤之一。今天，在癌症和其他疾病的治疗中使用天然化合物已经引起了研究人员的兴趣。藻类等海洋化合物具有抗癌作用。此外，海藻还具有营养价值。本研究旨在探讨鞭毛Hypnea flagelliformis （H. flagelliformis）提取物（甲醇、乙醚和正己烷）对肝癌线粒体的细胞毒性作用。材料与方法：用二乙基亚硝胺（DEN）和2-乙酰氨基芴（2-AAF）诱导大鼠肝细胞癌。然后对毒性参数进行评价。结果：鞭毛草提取物（250、500、1000µg/ml）对肝癌细胞线粒体均有明显毒性作用，对健康线粒体无影响。结论：鞭毛螺旋藻联合选定的药物治疗肝癌，有助于肝癌的治疗。

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Toxicity Effect of Hypnea flagelliformis Algae on Cancerous Mitochondria Obtained from Rat Model of Hepatocellular Carcinoma.

Background and objective: Hepatocellular carcinoma (HCC) is recognized as one of the major public health problems and deadly malignancies worldwide. Today, the use of compounds of natural origin in the treatment of cancer and other diseases has been of interest to researchers. Marine compounds such as algae have anti-cancer effects. In addition, Sea algae have nutritional value. This research is designed to investigate the cytotoxic effects of Hypnea flagelliformis (H. flagelliformis) extracts (methanolic, diethyl ether and n-hexane) on HCC mitochondria.

Material and method: HCC was induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in rats. Then, toxicity parameters were evaluated.

Results: The results showed that all H. flagelliformis extracts (250, 500 and 1000 µg/ml) significantly caused toxicity in HCC mitochondria, and no effect on healthy mitochondria was reported.

Conclusion: The results indicate that the use of H. flagelliformis along with selected drugs in the treatment of HCC can help in the treatment of this cancer.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.