Mohammad Hossein Hajali, Hamidreza Karbalaei-Musa, Mohammad Arbaghaei, Mohsen Rajaeinejad, Peyman Aslani, Iraj Mirzaii-Dizgah
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Serum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients.
Objective: Gastrointestinal cancer is one of the most common causes of death worldwide. As there are no clinical symptoms at the beginning of the disease, the diagnosis can be delayed and the stage increased. Timely diagnosis is therefore crucial. Since one of the factors involved in cell division is phosphate, and considering the benefits of using saliva, this study investigated the phosphate concentration in saliva and serum in patients with gastric and colorectal cancer as well as in healthy patients.
Methods: 26 patients with gastric and colorectal cancer confirmed by pathologic criteria were admitted to the oncology department of Imam Reza Hospital, and 30 healthy individuals participated in this study. Saliva and serum samples were collected in the morning. Phosphate concentration was determined using a photometric method.
Results: The average phosphate content in serum as well as in stimulated and unstimulated saliva was significantly lower in the patient group. In addition, the results showed that the patients reported more dry mouth than the control group despite increased salivary flow.
Conclusion: It appears that patients with malignant diseases of the gastrointestinal tract, such as colorectal cancer and gastric cancer, have lower serum and salivary phosphate levels than healthy individuals.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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