Apisara Somteds, Thanapat Suebrasri, Sophon Boonlue, Brian O. Patrick, Somdej Kanokmedhakul, Raymond J. Andersen, Kwanjai Kanokmedhakul
{"title":"乳酸黑孢菌培养产生的硫桥杂环倍半萜类黑孢素醇亚砜A和B","authors":"Apisara Somteds, Thanapat Suebrasri, Sophon Boonlue, Brian O. Patrick, Somdej Kanokmedhakul, Raymond J. Andersen, Kwanjai Kanokmedhakul","doi":"10.1021/acs.orglett.4c04304","DOIUrl":null,"url":null,"abstract":"The sesquiterpenoids nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have been isolated from cultures of the endophytic fungus <i>Nigrospora lacticolonia</i> harvested from the sunchoke <i>Helianthus tuberosus</i> L. collected in Thailand. Nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have 4/5/5/5/7 heterocyclic skeletons <b>3</b> featuring a sulfoxide bridge not previously found in a terpenoid natural product from any living source.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"25 1","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nigrosporinol Sulfoxides A and B, Sulfur-Bridged Heterocyclic Sesquiterpenoids Produced by Cultures of the Fungus Nigrospora lacticolonia\",\"authors\":\"Apisara Somteds, Thanapat Suebrasri, Sophon Boonlue, Brian O. Patrick, Somdej Kanokmedhakul, Raymond J. Andersen, Kwanjai Kanokmedhakul\",\"doi\":\"10.1021/acs.orglett.4c04304\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The sesquiterpenoids nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have been isolated from cultures of the endophytic fungus <i>Nigrospora lacticolonia</i> harvested from the sunchoke <i>Helianthus tuberosus</i> L. collected in Thailand. Nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have 4/5/5/5/7 heterocyclic skeletons <b>3</b> featuring a sulfoxide bridge not previously found in a terpenoid natural product from any living source.\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"25 1\",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2024-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.orglett.4c04304\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.orglett.4c04304","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Nigrosporinol Sulfoxides A and B, Sulfur-Bridged Heterocyclic Sesquiterpenoids Produced by Cultures of the Fungus Nigrospora lacticolonia
The sesquiterpenoids nigrosporinol sulfoxides A (1) and B (2) have been isolated from cultures of the endophytic fungus Nigrospora lacticolonia harvested from the sunchoke Helianthus tuberosus L. collected in Thailand. Nigrosporinol sulfoxides A (1) and B (2) have 4/5/5/5/7 heterocyclic skeletons 3 featuring a sulfoxide bridge not previously found in a terpenoid natural product from any living source.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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