多发性骨髓瘤患者诊断时是否需要骨髓环钻活检？

IF 2.7 4区医学 Q2 HEMATOLOGY Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-12-07 DOI:10.1016/j.clml.2024.12.004

Ana Gea, Tatiana Fernández, Sara Fernández-Luis, Juan J Domínguez-García, Irene Francés, Ana Tobalina, Rodrigo Cantera, Julia Bannatyne, Irene Gorostidi, María Oviedo, Juan M Cerezo, Raquel García, Andrés Insunza, Carmen Montes-Gaisán, Aránzazu Bermúdez, Santiago Montes-Moreno, Montserrat Briz, Enrique M Ocio

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引用次数: 0

摘要

多发性骨髓瘤（MM）的诊断需要骨髓（BM）浆细胞（PC）浸润≥10%，通过骨髓穿刺（BMA）或活检（BMB）检测。我们在189例患者中评估了这两种技术的一致性。在43例（23%）中，技术不一致，10例是由于样本质量差。在其余33例患者中，BMB诊断为MM， BMA检出< 10% PC， 16例有症状，17例有闷烧（SMM）。如果没有最初的BMB， 11%的人会被误诊；12%有症状的患者需要第二次BMA或BMB才能根据现行标准进行严格诊断。

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Is Bone Marrow Trephine Biopsy Necessary in Multiple Myeloma Patients at Diagnosis?

Multiple myeloma (MM) diagnosis requires ≥10% plasma cell (PC) infiltration in the bone marrow (BM), detected by bone marrow aspiration (BMA) or biopsy (BMB). We evaluated the concordance of these 2 techniques in 189 patients. In 43 cases (23%), the techniques were discordant, 10 due to poor sample quality. In the remaining 33 patients, BMB diagnosed MM, while BMA detected < 10% PC, being symptomatic in 16 patients and smouldering (SMM) in 17. Without an initial BMB, 11% would have been misdiagnosed; and 12% of symptomatic patients would require a second BMA or BMB for strict diagnosis according to current criteria.

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来源期刊

Clinical Lymphoma, Myeloma & Leukemia ONCOLOGY-HEMATOLOGY

CiteScore

2.70

自引率

3.70%

发文量

1606

审稿时长

26 days

期刊介绍： Clinical Lymphoma, Myeloma & Leukemia is a peer-reviewed monthly journal that publishes original articles describing various aspects of clinical and translational research of lymphoma, myeloma and leukemia. Clinical Lymphoma, Myeloma & Leukemia is devoted to articles on detection, diagnosis, prevention, and treatment of lymphoma, myeloma, leukemia and related disorders including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.