在固体组织和非血液液体中寻找与COVID-19相关的候选蛋白质生物标志物：最新进展

IF 2.1 4区生物学 Q3 BIOCHEMICAL RESEARCH METHODS PROTEOMICS – Clinical Applications Pub Date : 2024-12-30 DOI:10.1002/prca.202400117

Michal Alexovič, Csilla Uličná, Hadi Tabani, Ján Sabo

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引用次数: 0

摘要

目的：在COVID-19期间，蛋白质丰度的显著变化可能与疾病相关过程有关。基于质谱的covid -19相关生物标志物蛋白质组学可以帮助这一严重疾病的预后和诊断。设计：在这里，我们调查了有关COVID-19患者固体组织和非血液液体蛋白质组学分析的科学著作。涵盖了2022年至今出版的作品。结果：脑、淋巴结、心、脾、主动脉壁、肝、肾上腺、肾均作为实体脏器/组织。非血液液体包括呼气颗粒、气道粘液、唾液、拭子、初乳/乳和尿液。所提供的表格描述了分析covid -19相关候选蛋白质生物标志物的研究/实验平台。结论：即使在这一领域已经有了杰出的研究投入，也应该继续进行更深入的研究。翻译蛋白质组学到诊所，以帮助诊断和治疗策略，是一个非常重要的任务。分析的候选蛋白质生物标志物是等待临床决策和治疗的前景分子。

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In Search of Candidate Protein Biomarkers Related to COVID-19 in Solid Tissues and Non-Blood Fluids: An Update.

Purpose: During COVID-19, significant changes in protein abundance can be linked with disease-related processes. The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this severe disease.

Design: Here, we surveyed scientific works in terms of proteomic analysis of solid tissues and non-blood fluids from COVID-19 patients. Works published since 2022 to date have been covered.

Results: Brain, lymph nodes, heart, spleen, aorta walls, liver, adrenal gland and kidneys were investigated as solid organs/tissues. The non-blood fluids involved exhaled breath particles, airway mucus, saliva, swabs, colostrum/milk and urine. The provided table depicts studies/experimental platforms to analyse COVID-19-related candidate protein biomarkers.

Conclusion: Even eminent research input has been made in this field, continuation towards deeper findings should be made. Translation of proteomics into the clinics to help with diagnostics and therapeutical strategies, is a highly important task. The analysed candidate protein biomarkers are the perspective molecules for pending clinical decisions making and treatments.

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来源期刊

PROTEOMICS – Clinical Applications 医学-生化研究方法

CiteScore

5.20

自引率

5.00%

发文量

审稿时长

1 months

期刊介绍： PROTEOMICS - Clinical Applications has developed into a key source of information in the field of applying proteomics to the study of human disease and translation to the clinic. With 12 issues per year, the journal will publish papers in all relevant areas including: -basic proteomic research designed to further understand the molecular mechanisms underlying dysfunction in human disease -the results of proteomic studies dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers -the use of proteomics for the discovery of novel drug targets -the application of proteomics in the drug development pipeline -the use of proteomics as a component of clinical trials.