Niloufar Bineshfar, Faraz Changizi, Mina Farjam, Faezeh Sharafi, Basil K Williams
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引用次数: 0
摘要
目的：评估有和无慢性肾脏疾病（CKD）受试者的神经变性和绒毛膜视网膜厚度。方法：对PubMed、Web of Science、Scopus和Embase四个数据库从建立到2024年1月期间发表的英文文章，使用适当的关键词进行检索。如果他们报道了CKD患者与健康或非CKD对照者的视网膜或脉络膜层光学相干断层扫描（OCT）测量结果，则纳入出版物。我们使用随机效应模型来计算合并标准化平均差（SMD）估计值和95%置信区间（ci）。结果：12项研究，29340例患者被纳入定量综合。与对照组相比，CKD患者的平均视网膜厚度(SMD [CI]: -0.35 [-0.58；-0.12], P = 0.028)，脉络膜厚度(SMD [CI]: -1.84 [-4.17；0.49], P = 0.122)，黄斑神经节细胞-内丛状层（GC-IPL） (SMD [CI]: -0.58 [-0.78；-0.38]], P < 0.001)，乳头周围视网膜神经纤维层（RNFL）厚度(SMD [CI]: -0.32 [-0.44；-0.20], p < 0.001)。在排除和未排除的糖尿病CKD亚组中均观察到显著的RNFL变薄。结论：与对照组相比，CKD患者的视网膜、GC-IPL和RNFL明显变薄。
Systematic Review and Meta-Analysis of OCT measurements in patients with chronic kidney disease.
Purpose: To assess neurodegeneration and chorioretinal thickness in subjects with and without chronic kidney disease (CKD).
Methods: PubMed, Web of Science, Scopus and Embase were searched using proper keywords for articles published in the English language from their inception until January 2024. Publications were included if they reported optical coherence tomography (OCT) measurements of retinal or choroidal layers in patients with CKD compared to healthy or non-CKD controls. We used a random-effects model to calculate pooled standardized mean difference (SMD) estimates and 95% confidence intervals (CIs).
Results: Twelve studies, with 29,340 patients, were included in quantitative synthesis. In comparison to controls, patients with CKD had a significantly lower value for average retinal thickness (SMD [CI]: -0.35 [-0.58; -0.12], P = 0.028), choroidal thickness (SMD [CI]: -1.84 [-4.17; 0.49], P = 0.122), macular ganglion cell-inner plexiform layer (GC-IPL) (SMD [CI]: -0.58 [-0.78; -0.38]], P < 0.001), and peripapillary retinal nerve fiber layer (RNFL) thickness (SMD [CI]: -0.32 [-0.44; -0.20], P < 0.001). Significant RNFL thinning was observed in both diabetic CKD excluded and not excluded subgroups.
Conclusion: Compared to controls, the eyes of patients with CKD have significantly thinner retina, GC-IPL, and RNFL.
期刊介绍：
RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice.
In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color.
Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.
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