Flegel's Disease A Very Rare Skin Disease: A Case Report of Mother and Daughter in a Family.

Flegel's disease (FD) or hyperkeratosis lenticularis perstans (HLP) is an extremely exceptional skin disease typified by hyper-keratotic papules usually found on the lower extremities. Only the histopathological study is the confirmatory test for diagnosis this disease. The treatment of Flegel's disease is not yet settled as a standard one. Here we report two (2) cases of Flegel's disease in a family one was a 36-year-old woman, a housewife, presented with multiple mildly pruritic hyperkeratotic erythematous plaques and papules on both legs with hyperpigmented border and surrounding skin for 16 years and another one was A 20-year-old woman, daughter of case 1, student of a private university, presented with multiple moderately pruritic, hyperkeratotic, hyperpigmented discrete papules on her both middle part of legs for 6 years that was inherited as autosomal dominant manner were presented in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on 2021. A very few numbers of familial FD were reported globally.