肾上腺髓质素与肺动脉高压。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Danish medical journal Pub Date : 2024-11-15 DOI:10.61409/A07240498

Toshio Nishikimi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Hiromu Yanagisawa, Kenji Moriuchi, Yasuaki Nakagawa

{"title":"肾上腺髓质素与肺动脉高压。","authors":"Toshio Nishikimi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Hiromu Yanagisawa, Kenji Moriuchi, Yasuaki Nakagawa","doi":"10.61409/A07240498","DOIUrl":null,"url":null,"abstract":"Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes. Acute administration of AM improves the haemodynamics in patients with pulmonary hypertension, while chronic administration prevents the onset of pulmonary hypertension in animal models and delays its progression. Thus, AM is closely related to the pathophysiology of pulmonary hypertension and may be a promising therapeutic target.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"71 12","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adrenomedullin in pulmonary hypertension.\",\"authors\":\"Toshio Nishikimi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Hiromu Yanagisawa, Kenji Moriuchi, Yasuaki Nakagawa\",\"doi\":\"10.61409/A07240498\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes. Acute administration of AM improves the haemodynamics in patients with pulmonary hypertension, while chronic administration prevents the onset of pulmonary hypertension in animal models and delays its progression. Thus, AM is closely related to the pathophysiology of pulmonary hypertension and may be a promising therapeutic target.\",\"PeriodicalId\":11119,\"journal\":{\"name\":\"Danish medical journal\",\"volume\":\"71 12\",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Danish medical journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.61409/A07240498\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Danish medical journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.61409/A07240498","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

肾上腺髓质素（AM）具有很强的肺血管舒张作用。这些影响部分是由一氧化氮介导的。肺动脉高压患者血浆AM水平升高，与疾病严重程度和不良预后相关。急性给药AM可改善肺动脉高压患者的血流动力学，而慢性给药AM可在动物模型中预防肺动脉高压的发生并延缓其进展。因此，AM与肺动脉高压的病理生理密切相关，可能是一个有前景的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Adrenomedullin in pulmonary hypertension.

Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes. Acute administration of AM improves the haemodynamics in patients with pulmonary hypertension, while chronic administration prevents the onset of pulmonary hypertension in animal models and delays its progression. Thus, AM is closely related to the pathophysiology of pulmonary hypertension and may be a promising therapeutic target.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.