常染色体显性多囊肾病Notch2抑制与肾囊肿生长

IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Journal of The American Society of Nephrology Pub Date : 2025-01-02 DOI:10.1681/ASN.0000000592
Huiwen Ren, Chengsen Mu, Yuhan Wang, Yuanyuan Cheng, Yayan Hou, Yizhe Li, Na Liu, Zhuming Yin, Hui Xiong, Yupeng Chen, Tianxin Yang, Ying Yu, Yujun Shen
{"title":"常染色体显性多囊肾病Notch2抑制与肾囊肿生长","authors":"Huiwen Ren, Chengsen Mu, Yuhan Wang, Yuanyuan Cheng, Yayan Hou, Yizhe Li, Na Liu, Zhuming Yin, Hui Xiong, Yupeng Chen, Tianxin Yang, Ying Yu, Yujun Shen","doi":"10.1681/ASN.0000000592","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":10.3000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.\",\"authors\":\"Huiwen Ren, Chengsen Mu, Yuhan Wang, Yuanyuan Cheng, Yayan Hou, Yizhe Li, Na Liu, Zhuming Yin, Hui Xiong, Yupeng Chen, Tianxin Yang, Ying Yu, Yujun Shen\",\"doi\":\"10.1681/ASN.0000000592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":17217,\"journal\":{\"name\":\"Journal of The American Society of Nephrology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":10.3000,\"publicationDate\":\"2025-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The American Society of Nephrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1681/ASN.0000000592\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The American Society of Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1681/ASN.0000000592","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:Notch信号是一种保守的细胞间通讯机制,在细胞增殖和分化等过程中发挥着重要作用。然而,Notch信号在多囊肾病(PKD)进展中的具体作用尚不清楚。方法:我们研究了常染色体显性PKD (ADPKD)患者和两种ADPKD小鼠模型(早发和晚发)肾脏中Notch信号活性(Notch1-4)的变化。多种遗传学和药理学方法被用于探索PKD肾囊肿形成过程中的Notch2信号。结果:Notch2在ADPKD患者及小鼠肾组织中表达显著升高。新生儿和成年小鼠肾上皮细胞中Notch2细胞内结构域(NICD2)的靶向表达可导致囊肿形成和肾衰竭。机制上,Notch2/Hey2信号通过驱动ETS同源因子(Ehf)的表达促进肾上皮细胞增殖。Ehf的消耗延缓了NICD2过表达诱导的小鼠囊肿形成和肾衰竭。NOTCH2外显子34的功能获得突变(c.6426dupT)导致Hajdu-Cheney综合征患者的PKD,通过激活HEY2/EHF信号加速培养的人肾上皮细胞的细胞生长。最后,消融Notch2或使用携带脂质体(LIPO)/Notch2- sirna复合物的肾靶向纳米颗粒治疗,可显著抑制早发性ADPKD小鼠肾囊肿的生长。结论:Notch2信号部分通过上调Ehf表达促进肾囊肿生长,靶向Notch2可能是控制ADPKD囊肿生长的一种有希望的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
期刊最新文献
Testing Interventions that Address Kidney Health Disparities. Better Dialysis Care in the United States Requires New Payment Policy: No Patient Left Behind. Bundle Fix?: We Need an Act of Congress. Optimizing Quality Care within a Bundled Framework. Toward Noninvasive Biomarkers of Renal Senescence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1