Gisli G Jonsson, Alexander H Zielinski, Marton Berczeli, Timothy A Resch, Nuno Dias, Anders Wanhainen, Kevin Mani, Qasam Ghulam, Angelos Karelis, David Lindström
{"title":"一项多中心研究的中期结果：内脏内移植（InLoVE）的原位激光开窗。","authors":"Gisli G Jonsson, Alexander H Zielinski, Marton Berczeli, Timothy A Resch, Nuno Dias, Anders Wanhainen, Kevin Mani, Qasam Ghulam, Angelos Karelis, David Lindström","doi":"10.1016/j.ejvs.2024.12.041","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Emergent complex abdominal aortic diseases are challenging to treat. During in situ laser fenestration (ISLF), aortic branches are covered and flow is restored with in situ fenestration of the stent graft, with promising midterm results. This study aimed to expand on the limited body of knowledge of midterm outcomes of ISLF in renovisceral aortic pathology in a multicentre setting.</p><p><strong>Methods: </strong>Retrospective pooled data on consecutive ISLF cases of visceral aortic stent grafts undertaken from 2018 - 2023 in three aortic centres were analysed. Technical success was defined as successful vascularisation with a bridging stent graft and acceptable final angiographic series without signs of endoleak related to the bridging stent graft. Target vessel instability was defined as an endoleak related to the bridging stent graft, disconnection, kink, stenosis, occlusion of bridging stent, re-intervention on bridging stent graft, or rupture or death related to the bridging stent graft.</p><p><strong>Results: </strong>A total of 65 ISLFs were performed in 34 patients, with a mean age 74 years. The procedure was acute in 79%, and 35% were ruptures. Pre-stenting was performed on 56 target vessels (86%). Four patients (12%) died within 30 days; all presented with a rupture. Technical success was achieved in 61 of 65 (94%) ISLFs. All failed cannulations were in the renal arteries: three due to difficult angulations and one dissected during cannulation. Median follow up was 16 (interquartile range 5, 22) months. Cumulative survival at six months, one year, and two years was 88%, 80%, and 72%, respectively. In total, six (10%) target vessel instabilities were detected: two (3%) type III endoleaks, and four (7%) stent stenosis; all required re-lining. Freedom from target vessel instability at six months until the end of follow up was 89%. On the latest follow up scan, all successfully deployed ISLF bridging stents were patent (primary assisted patency 100%, 61 of 61) without signs of endoleak type 3.</p><p><strong>Conclusion: </strong>In situ laser fenestration is a promising tool for emergent endovascular procedures in complex anatomies.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In situ Laser Fenestrations of Visceral Endografts (InLoVE) Midterm Outcomes From a Multicentre Study.\",\"authors\":\"Gisli G Jonsson, Alexander H Zielinski, Marton Berczeli, Timothy A Resch, Nuno Dias, Anders Wanhainen, Kevin Mani, Qasam Ghulam, Angelos Karelis, David Lindström\",\"doi\":\"10.1016/j.ejvs.2024.12.041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Emergent complex abdominal aortic diseases are challenging to treat. During in situ laser fenestration (ISLF), aortic branches are covered and flow is restored with in situ fenestration of the stent graft, with promising midterm results. This study aimed to expand on the limited body of knowledge of midterm outcomes of ISLF in renovisceral aortic pathology in a multicentre setting.</p><p><strong>Methods: </strong>Retrospective pooled data on consecutive ISLF cases of visceral aortic stent grafts undertaken from 2018 - 2023 in three aortic centres were analysed. Technical success was defined as successful vascularisation with a bridging stent graft and acceptable final angiographic series without signs of endoleak related to the bridging stent graft. Target vessel instability was defined as an endoleak related to the bridging stent graft, disconnection, kink, stenosis, occlusion of bridging stent, re-intervention on bridging stent graft, or rupture or death related to the bridging stent graft.</p><p><strong>Results: </strong>A total of 65 ISLFs were performed in 34 patients, with a mean age 74 years. The procedure was acute in 79%, and 35% were ruptures. Pre-stenting was performed on 56 target vessels (86%). Four patients (12%) died within 30 days; all presented with a rupture. Technical success was achieved in 61 of 65 (94%) ISLFs. All failed cannulations were in the renal arteries: three due to difficult angulations and one dissected during cannulation. Median follow up was 16 (interquartile range 5, 22) months. Cumulative survival at six months, one year, and two years was 88%, 80%, and 72%, respectively. In total, six (10%) target vessel instabilities were detected: two (3%) type III endoleaks, and four (7%) stent stenosis; all required re-lining. Freedom from target vessel instability at six months until the end of follow up was 89%. 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In situ Laser Fenestrations of Visceral Endografts (InLoVE) Midterm Outcomes From a Multicentre Study.
Objective: Emergent complex abdominal aortic diseases are challenging to treat. During in situ laser fenestration (ISLF), aortic branches are covered and flow is restored with in situ fenestration of the stent graft, with promising midterm results. This study aimed to expand on the limited body of knowledge of midterm outcomes of ISLF in renovisceral aortic pathology in a multicentre setting.
Methods: Retrospective pooled data on consecutive ISLF cases of visceral aortic stent grafts undertaken from 2018 - 2023 in three aortic centres were analysed. Technical success was defined as successful vascularisation with a bridging stent graft and acceptable final angiographic series without signs of endoleak related to the bridging stent graft. Target vessel instability was defined as an endoleak related to the bridging stent graft, disconnection, kink, stenosis, occlusion of bridging stent, re-intervention on bridging stent graft, or rupture or death related to the bridging stent graft.
Results: A total of 65 ISLFs were performed in 34 patients, with a mean age 74 years. The procedure was acute in 79%, and 35% were ruptures. Pre-stenting was performed on 56 target vessels (86%). Four patients (12%) died within 30 days; all presented with a rupture. Technical success was achieved in 61 of 65 (94%) ISLFs. All failed cannulations were in the renal arteries: three due to difficult angulations and one dissected during cannulation. Median follow up was 16 (interquartile range 5, 22) months. Cumulative survival at six months, one year, and two years was 88%, 80%, and 72%, respectively. In total, six (10%) target vessel instabilities were detected: two (3%) type III endoleaks, and four (7%) stent stenosis; all required re-lining. Freedom from target vessel instability at six months until the end of follow up was 89%. On the latest follow up scan, all successfully deployed ISLF bridging stents were patent (primary assisted patency 100%, 61 of 61) without signs of endoleak type 3.
Conclusion: In situ laser fenestration is a promising tool for emergent endovascular procedures in complex anatomies.
期刊介绍：
The European Journal of Vascular and Endovascular Surgery is aimed primarily at vascular surgeons dealing with patients with arterial, venous and lymphatic diseases. Contributions are included on the diagnosis, investigation and management of these vascular disorders. Papers that consider the technical aspects of vascular surgery are encouraged, and the journal includes invited state-of-the-art articles.
Reflecting the increasing importance of endovascular techniques in the management of vascular diseases and the value of closer collaboration between the vascular surgeon and the vascular radiologist, the journal has now extended its scope to encompass the growing number of contributions from this exciting field. Articles describing endovascular method and their critical evaluation are included, as well as reports on the emerging technology associated with this field.
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