头发异烟肼水平预测结核痰培养转化。

IF 3.4 3区医学 Q2 INFECTIOUS DISEASES International Journal of Tuberculosis and Lung Disease Pub Date : 2025-01-01 DOI:10.5588/ijtld.24.0374

G Muzanyi, M Ntale, R Salata, M Joloba, J Mukonzo, D Mafigiri, P Mubiri, G Bbosa

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引用次数: 0

摘要

痰培养是诊断结核病和确认治疗结果的金标准。然而，周转时间为6-8周，这导致有关结核病患者护理的决策延迟。目的评价异烟肼发药水平对结核治疗8周时痰培养转化的预测作用。方法我们招募了56例结核病患者并开始治疗。我们在基线和第4、8和26周收集了痰和头发样本。痰液培养分别在固体和液体培养基上进行。毛发药物含量测定采用液相色谱-串联质谱法。结果我们排除了22名参与者（8名培养物被污染，10名无法产生痰，4名错过了第8周的访问）。其中结核痰培养阴性24例（86%），发药水平中位数为0.0514 ng/ml (IQR 0.1165 ~ 0.0314)；结核培养阳性4例（14.1%），发药水平中位数为0.0192 （IQR 0.0267 ~ 0.0132）。结论异烟肼毛中位水平≥0.05 ng/ml可预测结核病强化期结束时痰培养转化情况。

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Hair isoniazid levels predict TB sputum culture conversion.

BACKGROUNDSputum culture is the gold standard for diagnosing TB disease and confirming treatment outcomes. However, the turnaround time is 6-8 weeks, which leads to delays in decision-making regarding the care of TB patients.OBJECTIVETo evaluate isoniazid hair drug levels as a predictor of sputum culture conversion at 8 weeks of TB treatment.METHODSWe enrolled 56 TB patients and started them on treatment. We collected sputum and hair samples at baseline and Weeks 4, 8, and 26. Sputum culture was done on solid and liquid media. The hair drug levels assay was done using liquid chromatography-tandem mass spectrometry.RESULTSWe excluded 22 participants (8 with contaminated cultures, 10 were unable to produce sputum, and 4 missed the Week 8 visit). Of the remaining 28, about 24 (86%) were TB sputum culture-negative with a median hair drug level of 0.0514 ng/ml (IQR 0.1165-0.0314), and 4 (14.1%) were TB culture-positive, with a median hair drug level of 0.0192 (IQR 0.0267-0.0132).CONCLUSIONA median isoniazid hair level of ≥0.05 ng/ml may be predictive of sputum culture conversion by the end of the intensive phase of TB treatment..

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来源期刊

International Journal of Tuberculosis and Lung Disease 医学-传染病学

CiteScore

4.90

自引率

20.00%

发文量

266

审稿时长

2 months

期刊介绍： The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.