Are impulsive compulsive behaviors associated with levodopa-induced dyskinesia? A Brazilian cross-sectional study

Purpose of this research

To study the association between ICBs and LIDs and to assess the predictors of ICBs in this sample.

Methods

We intentionally evaluated 90 Brazilian PD patients younger than 60 in one evaluation that included the application of Questionnaire for Impulsive Compulsive Disorders - Current Short (QUIP-CS), Barratt Impulsive Scale-11 (BIS-11), Beck Depression Inventory-II (BDI-II), Unified Parkinson's Disease Rating Scale parts III and IV, Unified Dyskinesia Rating Scale (UDysRS), and a cognitive assessment.

Results

ICB group had a longer PD duration (8.8 ± 5.2 y vs. 6.3 ± 3.3 y, p = 0.01), higher LEDDs (852.1 ± 381.8 mg vs.669.8 ± 404.4 mg, p = 0.03), higher BIS-11 scores (64.3 ± 12.7 vs. 58.6 ± 9.7, p = 0.01) and higher historical off-dystonia sub-scores (3.9 ± 5.0 vs. 2.0 ± 4.0, p = 0,05). LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk in both logistic models performed. MCI did not relate to ICBs.

Conclusion

In this study, LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk.