Nataliia A. Strutynska , Volodymyr V. Balatskyi , Ruslan B. Strutynskyi , Yulia V. Goshovska , Lidiia A. Mys , Alina Yu. Luchkova , Maiia V. Denysova , Yuliia P. Korkach , Vladyslav R. Strutynskyi , Oksana O. Piven , Pawel Dobrzyn , Vadym F. Sagach
{"title":"吡哆醛-5-磷酸通过H2S/AKT/GSK3β信号轴减轻大鼠心脏年龄相关的代谢失衡。","authors":"Nataliia A. Strutynska , Volodymyr V. Balatskyi , Ruslan B. Strutynskyi , Yulia V. Goshovska , Lidiia A. Mys , Alina Yu. Luchkova , Maiia V. Denysova , Yuliia P. Korkach , Vladyslav R. Strutynskyi , Oksana O. Piven , Pawel Dobrzyn , Vadym F. Sagach","doi":"10.1016/j.mito.2024.102001","DOIUrl":null,"url":null,"abstract":"<div><div>Pyridoxal-5-phosphate (PLP) enhances the synthesis of endogenous hydrogen sulfide, a potent regulator of cell metabolism. We used 24-month-old rats to investigate the PLP mitoprotective function in the aging heart. We demonstrated improvement of mitochondrial bioenergetic functions, inhibition of mPTP opening after PLP administration. Moreover, PLP treatment increased glucose consumption and utilization, decreased lipid transport into the cells, but increased fatty acid β-oxidation, providing sufficient energy. An ECG study showed a significant improvement in cardiac function in PLP-treated old rats. Our data suggest that PLP may exert its effect through the H<sub>2</sub>S/AKT/GSK3β axis with further targeting of the Sirt1/PGC-1α signaling pathway.</div></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"81 ","pages":"Article 102001"},"PeriodicalIF":4.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pyridoxal-5-phosphate mitigates age-related metabolic imbalances in the rat heart through the H2S/AKT/GSK3β signaling axis\",\"authors\":\"Nataliia A. Strutynska , Volodymyr V. Balatskyi , Ruslan B. Strutynskyi , Yulia V. Goshovska , Lidiia A. Mys , Alina Yu. Luchkova , Maiia V. Denysova , Yuliia P. Korkach , Vladyslav R. Strutynskyi , Oksana O. Piven , Pawel Dobrzyn , Vadym F. Sagach\",\"doi\":\"10.1016/j.mito.2024.102001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Pyridoxal-5-phosphate (PLP) enhances the synthesis of endogenous hydrogen sulfide, a potent regulator of cell metabolism. We used 24-month-old rats to investigate the PLP mitoprotective function in the aging heart. We demonstrated improvement of mitochondrial bioenergetic functions, inhibition of mPTP opening after PLP administration. Moreover, PLP treatment increased glucose consumption and utilization, decreased lipid transport into the cells, but increased fatty acid β-oxidation, providing sufficient energy. An ECG study showed a significant improvement in cardiac function in PLP-treated old rats. Our data suggest that PLP may exert its effect through the H<sub>2</sub>S/AKT/GSK3β axis with further targeting of the Sirt1/PGC-1α signaling pathway.</div></div>\",\"PeriodicalId\":18606,\"journal\":{\"name\":\"Mitochondrion\",\"volume\":\"81 \",\"pages\":\"Article 102001\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mitochondrion\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1567724924001594\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mitochondrion","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1567724924001594","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Pyridoxal-5-phosphate mitigates age-related metabolic imbalances in the rat heart through the H2S/AKT/GSK3β signaling axis
Pyridoxal-5-phosphate (PLP) enhances the synthesis of endogenous hydrogen sulfide, a potent regulator of cell metabolism. We used 24-month-old rats to investigate the PLP mitoprotective function in the aging heart. We demonstrated improvement of mitochondrial bioenergetic functions, inhibition of mPTP opening after PLP administration. Moreover, PLP treatment increased glucose consumption and utilization, decreased lipid transport into the cells, but increased fatty acid β-oxidation, providing sufficient energy. An ECG study showed a significant improvement in cardiac function in PLP-treated old rats. Our data suggest that PLP may exert its effect through the H2S/AKT/GSK3β axis with further targeting of the Sirt1/PGC-1α signaling pathway.
期刊介绍：
Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.
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