{"title":"撤回:amp激酶抑制剂Dorsomorphin通过靶向Akt/mTOR通路降低结直肠癌细胞的增殖和迁移行为。","authors":"","doi":"10.1002/iub.2941","DOIUrl":null,"url":null,"abstract":"<p>RETRACTION: S. Ghanaatgar-Kasbi, F. Amerizadeh, F. Rahmani, S. M. Hassanian, M. Khazaei, G. A. Ferns and A. Avan, “Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway,” <i>IUBMB Life</i> 71, no. 12 (2019): 1929–1936, https://doi.org/10.1002/iub.2136.</p><p>The above article, published online on 30 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Efstathios S. Gonos; International Union of Biochemistry and Molecular Biology; and Wiley Periodicals LLC. The retraction has been agreed following an investigation into concerns raised by a third party which revealed that the TBHP image and the Dorso 5μM image in Figure 3b contained an overlap with images published elsewhere by some of the same authors. In both instances of duplication, the images were used to represent different experimental conditions. Furthermore, the western blot in Figure 4D has been inappropriately edited and there is evidence that the bands have been spliced without clearly marking the splice sites. The authors provided an explanation and some data but this was not considered sufficient to address the concerns. As a result, the editors have lost confidence in the data presented and consider the conclusions substantially compromised. The authors disagree with the retraction.</p>","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"77 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iub.2941","citationCount":"0","resultStr":"{\"title\":\"RETRACTION: Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway\",\"authors\":\"\",\"doi\":\"10.1002/iub.2941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>RETRACTION: S. Ghanaatgar-Kasbi, F. Amerizadeh, F. Rahmani, S. M. Hassanian, M. Khazaei, G. A. Ferns and A. Avan, “Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway,” <i>IUBMB Life</i> 71, no. 12 (2019): 1929–1936, https://doi.org/10.1002/iub.2136.</p><p>The above article, published online on 30 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Efstathios S. Gonos; International Union of Biochemistry and Molecular Biology; and Wiley Periodicals LLC. The retraction has been agreed following an investigation into concerns raised by a third party which revealed that the TBHP image and the Dorso 5μM image in Figure 3b contained an overlap with images published elsewhere by some of the same authors. In both instances of duplication, the images were used to represent different experimental conditions. Furthermore, the western blot in Figure 4D has been inappropriately edited and there is evidence that the bands have been spliced without clearly marking the splice sites. The authors provided an explanation and some data but this was not considered sufficient to address the concerns. As a result, the editors have lost confidence in the data presented and consider the conclusions substantially compromised. The authors disagree with the retraction.</p>\",\"PeriodicalId\":14728,\"journal\":{\"name\":\"IUBMB Life\",\"volume\":\"77 1\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-01-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iub.2941\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IUBMB Life\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iub.2941\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUBMB Life","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iub.2941","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
RETRACTION: Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway
RETRACTION: S. Ghanaatgar-Kasbi, F. Amerizadeh, F. Rahmani, S. M. Hassanian, M. Khazaei, G. A. Ferns and A. Avan, “Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway,” IUBMB Life 71, no. 12 (2019): 1929–1936, https://doi.org/10.1002/iub.2136.
The above article, published online on 30 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Efstathios S. Gonos; International Union of Biochemistry and Molecular Biology; and Wiley Periodicals LLC. The retraction has been agreed following an investigation into concerns raised by a third party which revealed that the TBHP image and the Dorso 5μM image in Figure 3b contained an overlap with images published elsewhere by some of the same authors. In both instances of duplication, the images were used to represent different experimental conditions. Furthermore, the western blot in Figure 4D has been inappropriately edited and there is evidence that the bands have been spliced without clearly marking the splice sites. The authors provided an explanation and some data but this was not considered sufficient to address the concerns. As a result, the editors have lost confidence in the data presented and consider the conclusions substantially compromised. The authors disagree with the retraction.
期刊介绍:
IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.