ck2依赖性SK通道功能障碍是阿尔茨海默病中神经元高兴奋性的贡献者。

IF 14.6 1区医学 Q1 NEUROSCIENCES Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-04 DOI:10.1016/j.tins.2024.12.006

Xiaojie Wei, Binggui Sun

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引用次数: 0

摘要

皮层和海马体的神经元高兴奋性代表了阿尔茨海默病（AD）的早期事件。在最近的一项研究中，Blankenship及其同事报道，在阿尔茨海默病小鼠中，腹侧被皮层（VTA）多巴胺神经元也具有高兴奋性，这种高兴奋性是由于酪蛋白激酶2 （CK2）依赖性SK通道功能障碍，这为阿尔茨海默病中异常神经元特性的潜在机制提供了新的见解。

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CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.

Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.

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