靶向巨噬细胞在癌症免疫治疗:前沿和挑战

IF 11.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Journal of Advanced Research Pub Date : 2025-01-06 DOI:10.1016/j.jare.2024.12.043
Yu’e Liu, Huabing Tan, Jingyuan Dai, Jianghua Lin, Kaijun Zhao, Haibo Hu, Chunlong Zhong
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引用次数: 0

摘要

癌症免疫治疗已经成为癌症治疗的一种突破性方法,主要通过操纵免疫细胞,特别是T细胞的采用和免疫检查点阻断来实现。然而,T细胞的操作遇到了巨大的障碍。巨噬细胞是先天免疫和适应性免疫之间的关键纽带,在吞噬、细胞因子分泌和抗原呈递中起着至关重要的作用。因此,巨噬细胞靶向治疗获得了极大的关注。我们的目标是为巨噬细胞靶向治疗提供最尖端的见解和未来的观点,促进新的和有效的癌症治疗的发展。迄今为止,巨噬细胞靶向治疗的前沿策略包括:改变其可塑性、利用car -巨噬细胞和靶向吞噬检查点。巨噬细胞以其显著的多样性和可塑性为特点,提供了独特的治疗靶点。在此背景下,我们批判性地分析了旨在将巨噬细胞从M2(肿瘤促进)表型转化为M1(肿瘤抑制)表型的创新策略。此外,我们还深入探讨了car -巨噬细胞的设计原理、发展进展和优势。此外,我们阐明了在巨噬细胞上靶向吞噬检查点所遇到的挑战,并提出了克服这些障碍的潜在策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Targeting macrophages in cancer immunotherapy: Frontiers and challenges

Background

Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and immune checkpoint blockade. Nevertheless, the manipulation of T cells encounters formidable hurdles. Macrophages, serving as the pivotal link between innate and adaptive immunity, play crucial roles in phagocytosis, cytokine secretion, and antigen presentation. Consequently, macrophage-targeted therapies have garnered significant attention.

Aim of review

We aim to provide the most cutting-edge insights and future perspectives for macrophage-targeted therapies, fostering the development of novel and effective cancer treatments.

Key scientific concepts of review

To date, the forefront strategies for macrophage targeting encompass: altering their plasticity, harnessing CAR-macrophages, and targeting phagocytosis checkpoints. Macrophages are characterized by their remarkable diversity and plasticity, offering a unique therapeutic target. In this context, we critically analyze the innovative strategies aimed at transforming macrophages from their M2 (tumor-promoting) to M1 (tumor-suppressing) phenotype. Furthermore, we delve into the design principles, developmental progress, and advantages of CAR-macrophages. Additionally, we illuminate the challenges encountered in targeting phagocytosis checkpoints on macrophages and propose potential strategies to overcome these obstacles.
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
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