Brad Amoateng, Mustafa Sheikh, Bernadette A. Fausto, Mark A. Gluck
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Participants completed a battery of self-reported health and demographic questionnaires, neuropsychological tests, and a short physical battery of both anthropometric and physical assessments. Linear mixed models were used to examine the relationship between baseline cardiovascular health markers and cognitive function up to 6 years of follow up.</p>\n </section>\n \n <section>\n \n <h3> Result</h3>\n \n <p>Higher diastolic blood pressure was significantly associated with worse Trail Making Test Part A (B = 0.035, p < .001), and Montreal Cognitive Assessment (B = 0.085, p = .0029) performance across time. Higher systolic blood pressure was significantly associated with poorer Trail Making Test Part A (B = 0.017, p < .001) and MoCA (B = 0.055, p < .001). Higher resting heart rate was significantly associated with worse Trail Making Test Part A (B = 0.018, p = .0031) and Part B (B = 0.085, p = .013), Controlled Oral Word Association Test (B = 0.036, p = .025), and Montreal Cognitive Assessment performance across time (B = 0.047, p = .046).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In cognitively unimpaired older African Americans, cardiovascular health markers are predictive biomarkers for early working memory decline in preclinical AD. Our findings may inform holistic clinical decision-making in AD prevention and personalized AD monitoring in patients with cardiovascular disease.</p>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 S8","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.095802","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular health predicts working memory decline among cognitively healthy older African Americans\",\"authors\":\"Brad Amoateng, Mustafa Sheikh, Bernadette A. Fausto, Mark A. 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引用次数: 0
摘要
背景：非裔美国人患心血管相关健康问题（如高血压、心血管疾病、中风、肥胖）和认知功能障碍（包括阿尔茨海默病（AD））的风险增加1,2。然而，很少有研究关注老年非裔美国人心血管健康和认知功能的纵向影响。本研究调查了老年非裔美国人心血管健康指标与认知之间的关系。方法从罗格斯大学-纽瓦克分校的一项纵向队列研究——非裔美国人健康老龄化途径中抽取836名参与者。参与者完成了一系列自我报告的健康和人口调查问卷，神经心理测试，以及人体测量和身体评估的简短物理测试。使用线性混合模型检查基线心血管健康指标与认知功能之间长达6年的随访关系。结果舒张压升高与临床试验A部分较差有显著相关性(B = 0.035, p <；.001)和蒙特利尔认知评估（B = 0.085, p = 0.0029）的跨时间表现。收缩压较高与临床试验A部分较差显著相关(B = 0.017, p <；.001)和MoCA (B = 0.055, p <；措施)。较高的静息心率与较差的Trail Making Test Part A （B = 0.018, p = 0.0031）、Part B （B = 0.085, p = 0.013）、Controlled Oral Word Association Test （B = 0.036, p = 0.025）和Montreal Cognitive Assessment （B = 0.047, p = 0.046）成绩显著相关。结论在认知功能未受损的老年非裔美国人中，心血管健康指标是临床前AD患者早期工作记忆下降的预测性生物标志物。我们的研究结果可能为心血管疾病患者的AD预防和个性化AD监测提供全面的临床决策。
Cardiovascular health predicts working memory decline among cognitively healthy older African Americans
Background
African Americans are at increased risk for cardiovascular-related health problems (e.g., hypertension, cardiovascular disease, stroke, obesity) and cognitive dysfunction, including Alzheimer’s disease (AD)1,2. However, few studies have looked at the longitudinal influence of cardiovascular health and cognitive function in older African Americans. This study investigated the relationship between cardiovascular health markers and cognition in older African Americans.
Method
836 participants were drawn from Pathways to Healthy Aging in African Americans, a longitudinal cohort study at Rutgers University–Newark. Participants completed a battery of self-reported health and demographic questionnaires, neuropsychological tests, and a short physical battery of both anthropometric and physical assessments. Linear mixed models were used to examine the relationship between baseline cardiovascular health markers and cognitive function up to 6 years of follow up.
Result
Higher diastolic blood pressure was significantly associated with worse Trail Making Test Part A (B = 0.035, p < .001), and Montreal Cognitive Assessment (B = 0.085, p = .0029) performance across time. Higher systolic blood pressure was significantly associated with poorer Trail Making Test Part A (B = 0.017, p < .001) and MoCA (B = 0.055, p < .001). Higher resting heart rate was significantly associated with worse Trail Making Test Part A (B = 0.018, p = .0031) and Part B (B = 0.085, p = .013), Controlled Oral Word Association Test (B = 0.036, p = .025), and Montreal Cognitive Assessment performance across time (B = 0.047, p = .046).
Conclusion
In cognitively unimpaired older African Americans, cardiovascular health markers are predictive biomarkers for early working memory decline in preclinical AD. Our findings may inform holistic clinical decision-making in AD prevention and personalized AD monitoring in patients with cardiovascular disease.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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