射血分数作为急性磷化铝中毒死亡率和发病率的预测指标。

IF 2.2 4区 医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2025-01-08 eCollection Date: 2025-01-01 DOI:10.1093/toxres/tfae232
Meray Medhat Shokry Zaghary, Hasnaa Ahmed Ahmed Ali, Asmaa Mohammed Khalaf Ahmed
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引用次数: 0

摘要

磷化铝毒是一种令人担忧的、众所周知的、具有高死亡率的有效自杀毒药。需要一种简单的工具来对预后不良的患者进行分类。该研究旨在评估射血分数作为急性磷化铝中毒病例死亡率和发病率预测因子的准确性。本研究纳入我院2021年1月至2024年1月急性磷酸铝中毒患者70例。男性占54.3%,女性占45.7%,平均年龄22.4±11.8岁。所有病例均以口服给药方式给药,84.3%的病例故意中毒。从患者的预后来看,62.9%的患者痊愈,37.1%的患者死亡。受试者工作特征曲线发现,射血分数低于37.5%时,准确率为96.8%,对死亡的判别良好,敏感性为100%,特异性为93.2%,阳性预测值为89.6%,阴性预测值为100%。射血分数低于52.5%,准确率89%,对并发症的鉴别良好,敏感性为83.3%,特异性为96.8%,阳性预测值为90.9%,阴性预测值为93.7%。因此,射血分数是预测急性磷化铝中毒的死亡率和并发症的重要工具,应在入院前24小时对每位患者进行评估,以促进这些患者的分诊。
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The performance of ejection fraction as a predictor of mortality and morbidity in acute aluminium phosphide poisoning.

Aluminium phosphide poison become an alarming, well-known, effective suicidal poison with a high mortality rate. There is a need for a simple tool that can triage patients with bad prognosis. The study aimed to assess the accuracy of ejection fraction as a predictor of mortality and morbidity in acute aluminium phosphide toxicity cases. The study involved 70 cases of acutely aluminium phosphide-poisoned patients in our hospital from January 2021 to January 2024. The study found that 54.3% of the cases were males and 45.7% were females, with a mean age of 22.4 ± 11.8 years old. The oral route was the route of administration of all cases, and the intention of poisoning was intentional in 84.3% of cases. Regarding the outcome of patients, 62.9% of the cases recovered, and 37.1% died. The Receiver Operating Characteristic Curve found that the ejection fraction below 37.5% had an accuracy rate of 96.8% with excellent discrimination for mortality, sensitivity of 100%, specificity of 93.2%, positive predictive value of 89.6%, and negative predictive value of 100%. The ejection fraction below 52.5% had an accuracy rate of 89% with good discrimination for complications, sensitivity of 83.3%, specificity of 96.8%, positive predictive value of 90.9%, and negative predictive value of 93.7%. So, the ejection fraction plays an essential tool in predicting mortality and complications in acute aluminium phosphide toxicity and should be assessed on every patient in the first 24 h of admission to facilitate the triage of these patients.

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Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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