羟氯喹致斯威特综合征1例报告及文献复习。

IF 3.5 4区 医学 Q1 DERMATOLOGY Acta dermato-venereologica Pub Date : 2025-01-08 DOI:10.2340/actadv.v105.41333
Gustavo Almeida-Silva, Joana Antunes, Inês Tribolet de Abreu, Filipe Monteiro, Pedro Vasconcelos, Luís Soares-Almeida, Paulo Filipe
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引用次数: 0

摘要

Sweet’s综合征(或急性发热性皮肤病)是一种中性粒细胞性皮肤病,其特征性表现包括特定的临床(发热和红斑-紫色水肿丘疹、斑块和结节)、实验室(中性粒细胞增多和炎症标志物增加)和组织学(无血管炎的皮肤中性粒细胞浸润)特征。其病理生理机制尚不清楚,但似乎有一种与炎性小体基因突变相关的自身炎症成分。它已细分为经典形式,恶性肿瘤相关,和药物诱导,根据其病因。这种情况通常对类固醇治疗反应迅速,但复发是常见的。本报告报道了一例极其罕见的羟氯喹诱导的Sweet’s综合征,并对文献进行了回顾,其中包括3例羟氯喹诱导的Sweet’s综合征和1例氯喹诱导的Sweet’s综合征。尽管相对容易诊断,但病因调查对临床医生提出了挑战,特别是在老年人人群中,因为可能存在几个混杂因素。需要进一步的研究来阐明这一实体背后的病理生理学,以进一步促进诊断和治疗策略。
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Hydroxychloroquine-induced Sweet's Syndrome: A Case Report and Literature Review.

Sweet's syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (dermal neutrophilic infiltrate without vasculitis) features. Its pathophysiology is poorly understood but there seems to be an auto-inflammatory component related to mutations in inflammasome genes. It has been subdivided into its classic form, malignancy-associated, and drug-induced, according to its aetiology. The condition usually responds rapidly to steroid therapy, but recurrences are common. This report presents an extremely rare case of hydroxychloroquine-induced Sweet's syndrome, plus a review of the literature, which encompasses 3 previous cases of Sweet's syndrome induced by hydroxychloroquine and 1 induced by chloroquine. Despite being relatively easy to diagnose, aetiological investigation poses challenges to the clinician, especially in the elderly population, as several confounding factors might be present. Further studies are necessary to shed light on the pathophysiology behind this entity, to further facilitate diagnostic workup and treatment strategies.

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来源期刊
Acta dermato-venereologica
Acta dermato-venereologica 医学-皮肤病学
CiteScore
4.90
自引率
2.80%
发文量
210
审稿时长
6-12 weeks
期刊介绍: Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.
期刊最新文献
A 37-year-old Woman with a Solitary Flaccid Bulla on the Left Wrist: A Quiz. Recurrent Neutrophilic Dermatosis of the Face Successfully Treated with Potassium Iodide. Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis. A Case of Tertiary Syphilis with Unilateral Pupillary Abnormality. Basal Cell Nevus Syndrome and Sporadic Basal Cell Carcinoma: A Comparative Study of Clinicopathological Features.
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