香草酸的抗肿瘤作用及分子机制。

IF 2.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Discover. Oncology Pub Date : 2025-01-08 DOI:10.1007/s12672-025-01746-6
Xunxing Hao, Zhixiao Gao, Mingzhe Hu
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引用次数: 0

摘要

香草酸(Vanillic Acid, VA)是从当归、人参等中药中提取的芳香酸,具有很强的抗癌活性,能抑制多种恶性肿瘤的发生和发展。这篇综述强调了VA发挥其抗癌活性的主要机制,包括诱导细胞凋亡,特别是促进细胞内活性氧(ROS)的产生,从而引发线粒体凋亡。此外,VA破坏癌细胞周期,在G1期阻止大多数癌细胞,减少细胞迁移、侵袭、血管生成,增强化疗药物的治疗效果,同时最大限度地减少不良反应。本文就VA的抗肿瘤作用及其机制进行综述,旨在为科学家和临床医生研究抗肿瘤治疗策略提供一些参考。
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Anti-tumor role and molecular mechanism of vanillic acid.

Vanillic Acid (VA) is an aromatic acid extracted from traditional Chinese medicine such as Angelica sinensis and Panax ginseng, which has demonstrated potent anti-cancer activity, inhibiting the onset and progression of various malignant tumors. This review highlights the principal mechanism by which VA exerts its anticancer activity, including apoptosis induction, specifically promoting the generation of intracellular reactive oxygen species (ROS), which in turn triggers mitochondrial apoptosis. Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions. This paper offers a comprehensive review of VA's anti-tumor effects and underlying mechanisms, aiming to provide some references for scientists and clinical physicians in the research of anti-tumor therapeutic strategies.

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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
期刊最新文献
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