法医基因标记是否透露了更多关于我们的信息?(审查)。

IF 2.2 3区 医学 Q1 MEDICINE, LEGAL International Journal of Legal Medicine Pub Date : 2025-01-08 DOI:10.1007/s00414-024-03395-w
Carlota Manglano de la Fuente, Sara Palomo-Díez
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引用次数: 0

摘要

构成CoDIS包的20个已建立的str必须遵守国家和国际隐私权和法律政策。目前的研究表明,在法医环境中使用的某些遗传标记可能会显示有关其他邻近标记的信息,这些标记可能反映个人的某些私人特征。因此,我们的目的是通过文献综述,找出CoDIS建立的一些STRs等位基因与医学和表型状况之间是否确实存在关联,以检验这个问题是否有真正的依据。为了进行这项综述,我们在不同的数据库中进行了系统的检索,并对所收集的文章进行了批判性的评估,并对所有相关研究进行了综合。结果普遍表明,个体的私人表型数据可以从CoDIS建立的某些str中得知,因为它们与邻近基因相关。然而,大多数论文指出,实际上没有一个已建立的关联提供因果关系的证据,而是一些str和表型之间的关系。
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Do forensic genetic markers disclose more information about us than they should? (A review).

The 20 established STRs that make up the CoDIS package must comply with national and international privacy rights and legal policies. Current research reveals that it is possible that certain genetic markers, used in forensic contexts, may show information about other neighboring markers that could reflect certain private characteristics of individuals. Therefore, we will aim to find out, through a literature review, whether there may indeed be associations between some of the STRs alleles established by CoDIS and medical and phenotypic conditions, with the aim of checking whether this problem has a real basis. To carry out this review, a systematic search has been carried out in different databases, as well as a critical evaluation of the articles collected and a synthesis of all the relevant studies. The results generally show that private phenotypic data of the individual can be known from certain STRs established by CoDIS, due to their association with neighboring genes. However, most of the papers state that practically none of the established associations offer proof of causality, but rather a relationship between some STRs and a phenotype.

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来源期刊
CiteScore
5.80
自引率
9.50%
发文量
165
审稿时长
1 months
期刊介绍: The International Journal of Legal Medicine aims to improve the scientific resources used in the elucidation of crime and related forensic applications at a high level of evidential proof. The journal offers review articles tracing development in specific areas, with up-to-date analysis; original articles discussing significant recent research results; case reports describing interesting and exceptional examples; population data; letters to the editors; and technical notes, which appear in a section originally created for rapid publication of data in the dynamic field of DNA analysis.
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