法国儿童、青少年和年轻人的精神卫生保健利用和处方率。

IF 10.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL JAMA Network Open Pub Date : 2025-01-02 DOI:10.1001/jamanetworkopen.2024.52789
Guillaume Fond, Vanessa Pauly, Yann Brousse, Pierre-Michel Llorca, Samuele Cortese, Masoud Rahmati, Christoph U Correll, Corentin J Gosling, Michele Fornaro, Marco Solmi, Lee Smith, Nicola Veronese, Dong Keon Yon, Pascal Auquier, Antoine Duclos, Laurent Boyer
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引用次数: 0

摘要

重要性:2019冠状病毒病大流行加剧了年轻人面临的心理健康挑战,分析大流行后的趋势至关重要。目的:了解2019冠状病毒病(COVID-19)大流行前后儿童、青少年和青壮年的精神卫生保健利用情况和处方率。设计、环境和参与者:这项基于人群的时间趋势研究使用中断时间序列分析来检查25岁及以下法国人群的精神卫生保健和处方模式。2016年1月至2023年6月法国国家健康保险数据库的汇总数据。数据分析时间为2023年9月至2024年2月。主要结果和测量方法:计算了至少进行过一次精神科门诊会诊的人数、精神科全日制住院的人数、有自杀企图的人数和接受精神药物治疗的人数。数据按年龄组和性别分层。准泊松回归对非季节性数据建模,估计大流行前后斜率差异的相对风险(RR)和95% CI。结果:该研究包括大约2000万25岁及以下的个体(2016年为20 829 566个体,2022年为20 697 169个体)。2016年,人口包括10 208 277 / 20 829 566名女性参与者(49.0%)和6 091 959(29.2%),年龄在18至25岁。2022年的比例与此相似。与大流行前相比,大流行后使用精神卫生保健服务的人数显著增加,尤其是在女性和13岁及以上的年轻人中。女性精神科门诊问诊增加(RR, 1.13;95% CI, 1.07-1.20), 13 - 17岁个体(RR, 1.15;95% CI, 1.06-1.23),以及18 - 25岁的个体(RR, 1.08;95% ci, 1.03-1.14)。女性自杀未遂住院率增加(RR, 1.14;95% CI, 1.02-1.27)和18 - 25岁的个体(RR, 1.07;95% ci, 1.03-1.12)。关于精神药物,2016年至2022年期间,除催眠药外,几乎所有类别的女性处方都有所增加,在大流行后时期增长尤为显著。对于男性,只有抗抑郁药处方增加(RR, 1.03;95% CI, 1.01-1.06),哌醋甲酯(RR, 1.09;95% CI, 1.06-1.12),以及酒精使用障碍的药物处方(RR, 1.08;95% CI, 1.04-1.13),并且这些增加不如女性明显(抗抑郁药:RR, 1.13, 95% CI, 1.09-1.16;哌甲酯:RR, 1.15;95% ci, 1.13-1.18;酒精使用依赖:RR, 1.12;95% ci, 1.08-1.16)。治疗严重精神疾病的药物,如锂或氯氮平,从6岁开始被开得更频繁。结论和相关性:在这项研究中,一项中断的时间序列分析发现,在2019冠状病毒病大流行之后,法国年轻女性的心理健康状况明显恶化,加剧了在大流行前已经观察到的恶化趋势。
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Mental Health Care Utilization and Prescription Rates Among Children, Adolescents, and Young Adults in France.

Importance: Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical.

Objective: To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic.

Design, setting, and participants: This population-based time trend study used an interrupted time series analysis to examine mental health care and prescription patterns among the French population 25 years and younger. Aggregated data from the French national health insurance database from January 2016 to June 2023. Data were analyzed from September 2023 to February 2024.

Main outcomes and measures: The number of individuals with at least 1 outpatient psychiatric consultation, those admitted for full-time psychiatric hospitalization, those with a suicide attempt, and those receiving psychotropic medication was computed. Data were stratified by age groups and sex. Quasi-Poisson regression modeled deseasonalized data, estimating the relative risk (RR) and 95% CI for differences in slopes before and after the pandemic.

Results: This study included approximately 20 million individuals 25 years and younger (20 829 566 individuals in 2016 and 20 697 169 individuals in 2022). In 2016, the population consisted of 10 208 277 of 20 829 566 female participants (49.0%) and 6 091 959 (29.2%) aged 18 to 25 years. Proportions were similar in 2022. Significant increases in mental health care utilization were observed postpandemic compared with the prepandemic period, especially among females and young people aged 13 years and older. Outpatient psychiatric consultations increased among women (RR, 1.13; 95% CI, 1.07-1.20), individuals aged 13 to 17 years (RR, 1.15; 95% CI, 1.06-1.23), and individuals aged 18 to 25 years (RR, 1.08; 95% CI, 1.03-1.14). Hospitalizations for suicide attempt increased among women (RR, 1.14; 95% CI, 1.02-1.27) and individuals aged 18 to 25 years (RR, 1.07; 95% CI, 1.03-1.12). Regarding psychotropic medications, almost all classes, except hypnotics, increased in prescriptions between 2016 and 2022 for females, with a particularly marked rise in the postpandemic period. For men, only increases in the prescriptions of antidepressants (RR, 1.03; 95% CI, 1.01-1.06), methylphenidate (RR, 1.09; 95% CI, 1.06-1.12), and medications prescribed for alcohol use disorders (RR, 1.08; 95% CI, 1.04-1.13) were observed, and these increases were less pronounced than for women (antidepressant: RR, 1.13, 95% CI, 1.09-1.16; methylphenidate: RR, 1.15; 95% CI, 1.13-1.18; alcohol use dependence: RR, 1.12; 95% CI, 1.08-1.16). Medications reserved for severe mental health situations, such as lithium or clozapine, were prescribed more frequently starting at the age of 6 years.

Conclusions and relevance: In this study, an interrupted time-series analysis found a marked deterioration in the mental health of young women in France in the after the COVID-19 pandemic, accentuating a trend of deterioration that was already observed in the prepandemic period.

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来源期刊
JAMA Network Open
JAMA Network Open Medicine-General Medicine
CiteScore
16.00
自引率
2.90%
发文量
2126
审稿时长
16 weeks
期刊介绍: JAMA Network Open, a member of the esteemed JAMA Network, stands as an international, peer-reviewed, open-access general medical journal.The publication is dedicated to disseminating research across various health disciplines and countries, encompassing clinical care, innovation in health care, health policy, and global health. JAMA Network Open caters to clinicians, investigators, and policymakers, providing a platform for valuable insights and advancements in the medical field. As part of the JAMA Network, a consortium of peer-reviewed general medical and specialty publications, JAMA Network Open contributes to the collective knowledge and understanding within the medical community.
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