长链非编码rna在糖尿病性心肌病中的潜在功能:作为生物标志物和运动训练的治疗靶点。

IF 2.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI:10.1007/s12265-024-10586-8
Jie Hu, Xinwen Miao, Li-Hua Yu
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引用次数: 0

摘要

最近的研究强调了运动对糖尿病性心肌病(DCM)的有益作用,增加了越来越多的证据,强调运动在改善健康结果中的作用。尽管如此,在积极将运动作为DCM管理治疗干预措施的医疗保健提供者数量上仍然存在显著差距。此外,运动调节lncrna的表达,lncrna在DCM进展中起关键作用。进一步研究这种关系可能有助于发现新的生物标志物和DCM的治疗靶点。本文综述了在DCM中鉴定lncrna生物标志物的最新进展,总结了目前关于lncrna失调及其分子机制的知识。此外,它为lncrna的机制作用提供了新的见解,突出了它们作为DCM的生物标志物和治疗靶点的潜力。总的来说,本综述旨在为未来的研究提供信息,并强调解决糖尿病相关心血管疾病的重要性,以潜在地改善临床结果。
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Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training.

Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body of evidence that underscores the role of exercise in improving health outcomes. Despite this, a notable gap persists in the number of healthcare providers who actively prescribe exercise as a therapeutic intervention for DCM management. In addition, exercise modulates the expression of lncRNAs, which play a pivotal role in DCM progression. Further investigation into this relationship may facilitate the identification of novel biomarkers and therapeutic targets for DCM. This review consolidates recent advances in identifying lncRNAs biomarkers in DCM, summarizing the current knowledge on dysregulated lncRNAs and their molecular mechanisms. Additionally, it offers new insights into the mechanistic roles of lncRNAs, highlighting their potential as biomarkers and therapeutic targets for DCM. Overall, this review aims to inform future research and reinforce the significance of addressing diabetes-related cardiovascular diseases to potentially improve clinical outcomes.

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来源期刊
Journal of Cardiovascular Translational Research
Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.10
自引率
2.90%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.
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