接受单克隆抗体相关治疗的自身免疫性疾病患者的微孢子虫病

IF 3.6 3区 生物学 Q2 MYCOLOGY Mycopathologia Pub Date : 2025-01-09 DOI:10.1007/s11046-024-00918-2
Ramzi Kechaou, Denis Magne, Yaye Senghor, Cécile Brin, Karine Louvion, Laurene Parrot, Marjolaine Morgand, Céline Nourrisson, Philippe Poirier, Jeanne Bigot, Christophe Hennequin, Alicia Moreno-Sabater
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引用次数: 0

摘要

我们报告了4例接受长期单克隆抗体治疗的自身免疫性疾病患者的连氏肠胞虫感染。两名患者患有炎症性肠病并接受抗tnf治疗,而另外两名患者患有系统性红斑狼疮并累及肾脏,接受抗cd20或抗blys蛋白治疗。在抽样时,四分之三的患者因腹泻并腹痛而无肠道炎症或出血而就诊。第四名患者没有肠道疾病。本研究检测到的微孢子虫基因型为S9、C、Wildboard3,其中1例患者携带S6和EBCMAP-038两种基因型。微孢子虫感染的治疗包括阿苯达唑和减少免疫抑制治疗,但另外2例患者未实施特异性治疗。总之,小孢子虫感染发生在长期单克隆抗体治疗的自身免疫性疾病患者中。在这一人群中应仔细评估诊断,在开始治疗干预措施之前进行彻底的利益-风险分析是必不可少的。
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Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy.

We present Enterocytozoon bieneusi infection in four patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Two patients suffered from inflammatory bowel disease and received anti-TNF therapies, whereas two other patients suffered from systemic lupus erythematosus with renal involvement and received anti-CD20 or anti-BLyS protein therapies. Three out of four patients consulted for diarrhea with abdominal pain without intestinal inflammation or bleeding at the time of sampling. The fourth patient did not declare intestinal troubles. Microsporidia genotype detected in this study were S9, C, Wildboard3 with one patient harboring 2 genotypes S6 and EBCMAP-038. Management of microsporidia infection included albendazole and reduction of immunosuppression treatment, but no specific treatment was implemented in two other patients. In conclusion, microsporidia infection occurs in patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Diagnosis should be carefully assessed in this population and a thorough benefit-risk analysis is essential prior to initiating therapeutic interventions.

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来源期刊
Mycopathologia
Mycopathologia 生物-真菌学
CiteScore
6.80
自引率
3.60%
发文量
76
审稿时长
3 months
期刊介绍: Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.
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