CDKN2A缺失对食管癌演变的影响取决于环境和时间。

IF 23.5 1区医学 Q1 ONCOLOGY Nature cancer Pub Date : 2025-01-07 DOI:10.1038/s43018-024-00877-z

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Effects of CDKN2A loss on evolution of esophageal adenocarcinoma depend on context and time

Loss of CDKN2A is known to drive the progression of several cancers, including esophageal adenocarcinoma (EAC). Genetic analyses of samples of Barrett’s esophagus (EAC precursor condition) show that early loss of CDKN2A delays EAC initiation. Moreover, the concomitant loss of other genes in the same chromosomal locus has different effects depending on context.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.