Nicolaas Koen Vermeijden, Leilani de Silva, Supun Manathunga, Daphne Spoolder, Judith Korterink, Arine Vlieger, Shaman Rajindrajith, Marc Benninga
{"title":"儿童功能性腹痛疾病的流行病学：一项荟萃分析。","authors":"Nicolaas Koen Vermeijden, Leilani de Silva, Supun Manathunga, Daphne Spoolder, Judith Korterink, Arine Vlieger, Shaman Rajindrajith, Marc Benninga","doi":"10.1542/peds.2024-067677","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Functional abdominal pain disorders (FAPDs) are debilitating disorders with unknown current prevalence.</p><p><strong>Objective: </strong>To estimate global prevalence rates of FAPDs, their entities, and variations by diagnostic criteria, geography, gender, and age.</p><p><strong>Data sources: </strong>Medline, Embase, CINAHL, PsycInfo, and Cochrane Library were searched through October 14, 2024.</p><p><strong>Study selection: </strong>Epidemiological studies of birth cohorts, school based, and from general population samples reporting FAPD prevalence in children (aged 4-18 years) using the Rome criteria.</p><p><strong>Data extraction: </strong>Two researchers independently performed screening, data extraction, and quality assessment.</p><p><strong>Results: </strong>A total of 66 studies, encompassing 201 134 participants from 29 countries, were included. The estimated global pooled prevalence of FAPDs was 11.7% (95% CI, 10.5%-13.1%). The most prevalent type was irritable bowel syndrome (5.8%; 95% CI, 4.5-7.4%), while functional abdominal pain-not otherwise specified was least prevalent (1.2%; 95% CI, 0.7%-2.1%)). Prevalence was highest using Rome III (13.2%; 95% CI, 11.3%-15.3%) and lowest under Rome IV criteria (9.0%; 95% CI, 6.7%-12.0%; P = .05). Girls had higher prevalence (14.4%; 95% CI, 12.5%-16.6%) than boys (9.4%; 95% CI, 7.8%-11.4%; P < .01). FAPDs were nonsignificantly more prevalent in Asia (13.0%; 95% CI, 10.4%-16.3%) compared to Europe (8.3%; 95% CI, 6.4%-10.7%) and North America (7.7%; 95% CI, 4.3-13.6; P = .09). No differences by age (P = .14) were recorded. Contributing factors include anxiety, depression, stress, negative life events, and poor sleep.</p><p><strong>Limitations: </strong>Language restrictions, significant interstudy heterogeneity, and underrepresentation from Africa.</p><p><strong>Conclusions and relevance: </strong>FAPDs affect over 1 in 9 children worldwide, with higher prevalence in girls and those with psychological stressors.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis.\",\"authors\":\"Nicolaas Koen Vermeijden, Leilani de Silva, Supun Manathunga, Daphne Spoolder, Judith Korterink, Arine Vlieger, Shaman Rajindrajith, Marc Benninga\",\"doi\":\"10.1542/peds.2024-067677\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Functional abdominal pain disorders (FAPDs) are debilitating disorders with unknown current prevalence.</p><p><strong>Objective: </strong>To estimate global prevalence rates of FAPDs, their entities, and variations by diagnostic criteria, geography, gender, and age.</p><p><strong>Data sources: </strong>Medline, Embase, CINAHL, PsycInfo, and Cochrane Library were searched through October 14, 2024.</p><p><strong>Study selection: </strong>Epidemiological studies of birth cohorts, school based, and from general population samples reporting FAPD prevalence in children (aged 4-18 years) using the Rome criteria.</p><p><strong>Data extraction: </strong>Two researchers independently performed screening, data extraction, and quality assessment.</p><p><strong>Results: </strong>A total of 66 studies, encompassing 201 134 participants from 29 countries, were included. The estimated global pooled prevalence of FAPDs was 11.7% (95% CI, 10.5%-13.1%). The most prevalent type was irritable bowel syndrome (5.8%; 95% CI, 4.5-7.4%), while functional abdominal pain-not otherwise specified was least prevalent (1.2%; 95% CI, 0.7%-2.1%)). Prevalence was highest using Rome III (13.2%; 95% CI, 11.3%-15.3%) and lowest under Rome IV criteria (9.0%; 95% CI, 6.7%-12.0%; P = .05). Girls had higher prevalence (14.4%; 95% CI, 12.5%-16.6%) than boys (9.4%; 95% CI, 7.8%-11.4%; P < .01). FAPDs were nonsignificantly more prevalent in Asia (13.0%; 95% CI, 10.4%-16.3%) compared to Europe (8.3%; 95% CI, 6.4%-10.7%) and North America (7.7%; 95% CI, 4.3-13.6; P = .09). No differences by age (P = .14) were recorded. Contributing factors include anxiety, depression, stress, negative life events, and poor sleep.</p><p><strong>Limitations: </strong>Language restrictions, significant interstudy heterogeneity, and underrepresentation from Africa.</p><p><strong>Conclusions and relevance: </strong>FAPDs affect over 1 in 9 children worldwide, with higher prevalence in girls and those with psychological stressors.</p>\",\"PeriodicalId\":20028,\"journal\":{\"name\":\"Pediatrics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-01-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1542/peds.2024-067677\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1542/peds.2024-067677","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis.
Context: Functional abdominal pain disorders (FAPDs) are debilitating disorders with unknown current prevalence.
Objective: To estimate global prevalence rates of FAPDs, their entities, and variations by diagnostic criteria, geography, gender, and age.
Data sources: Medline, Embase, CINAHL, PsycInfo, and Cochrane Library were searched through October 14, 2024.
Study selection: Epidemiological studies of birth cohorts, school based, and from general population samples reporting FAPD prevalence in children (aged 4-18 years) using the Rome criteria.
Data extraction: Two researchers independently performed screening, data extraction, and quality assessment.
Results: A total of 66 studies, encompassing 201 134 participants from 29 countries, were included. The estimated global pooled prevalence of FAPDs was 11.7% (95% CI, 10.5%-13.1%). The most prevalent type was irritable bowel syndrome (5.8%; 95% CI, 4.5-7.4%), while functional abdominal pain-not otherwise specified was least prevalent (1.2%; 95% CI, 0.7%-2.1%)). Prevalence was highest using Rome III (13.2%; 95% CI, 11.3%-15.3%) and lowest under Rome IV criteria (9.0%; 95% CI, 6.7%-12.0%; P = .05). Girls had higher prevalence (14.4%; 95% CI, 12.5%-16.6%) than boys (9.4%; 95% CI, 7.8%-11.4%; P < .01). FAPDs were nonsignificantly more prevalent in Asia (13.0%; 95% CI, 10.4%-16.3%) compared to Europe (8.3%; 95% CI, 6.4%-10.7%) and North America (7.7%; 95% CI, 4.3-13.6; P = .09). No differences by age (P = .14) were recorded. Contributing factors include anxiety, depression, stress, negative life events, and poor sleep.
Limitations: Language restrictions, significant interstudy heterogeneity, and underrepresentation from Africa.
Conclusions and relevance: FAPDs affect over 1 in 9 children worldwide, with higher prevalence in girls and those with psychological stressors.
期刊介绍：
The Pediatrics® journal is the official flagship journal of the American Academy of Pediatrics (AAP). It is widely cited in the field of pediatric medicine and is recognized as the leading journal in the field.
The journal publishes original research and evidence-based articles, which provide authoritative information to help readers stay up-to-date with the latest developments in pediatric medicine. The content is peer-reviewed and undergoes rigorous evaluation to ensure its quality and reliability.
Pediatrics also serves as a valuable resource for conducting new research studies and supporting education and training activities in the field of pediatrics. It aims to enhance the quality of pediatric outpatient and inpatient care by disseminating valuable knowledge and insights.
As of 2023, Pediatrics has an impressive Journal Impact Factor (IF) Score of 8.0. The IF is a measure of a journal's influence and importance in the scientific community, with higher scores indicating a greater impact. This score reflects the significance and reach of the research published in Pediatrics, further establishing its prominence in the field of pediatric medicine.
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