氧化锌纳米颗粒介导的杨梅和香薷制剂的抗糖尿病和抑菌活性。

Q3 Medicine Medical Journal of Malaysia Pub Date : 2025-01-01
R V Geetha, K Shwetha, R Annika, S Rajeshkumar, M Pradeep, A Jayasree
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引用次数: 0

摘要

氧化锌纳米颗粒(ZnO NPs)具有广泛的生物医学应用,主要用于抗炎、抗癌、抗糖尿病和抗微生物等生物医学应用,因为它们具有较小的毒性和非常强的相容性。金属锌是一种微量的人体必需无机元素。氧化锌NPs也是GRAS物质(公认安全物质)。本研究的主要目的是利用红茶和丁香介导的草药配方合成氧化锌纳米颗粒,并筛选其抗菌和抗糖尿病特性。材料和方法:采用绿色合成法合成了红茶和丁香介导的氧化锌NPs。采用琼脂孔扩散法测定其对口腔病原菌的抑菌活性,采用-淀粉酶抑制法测定其对糖尿病的抑菌活性。结果:以红茶和丁香提取物为原料,成功合成了氧化锌纳米粒子。采用紫外可见分光光度法和扫描电镜对芦笋(红茶)和丁香(丁香)介导的氧化锌NPs进行了表征。绿色合成的ZnO NPs对金黄色葡萄球菌、粪芽孢杆菌、变形葡萄球菌和白色念珠菌的抑制区分别为12 mm、11 mm、9 mm和11 mm,显示出良好的抑菌活性。在抗糖尿病活性方面,绿色合成的ZnO NPs在最大浓度为50µg/mL时,最大抑制率高达80%。结论:以绿茶和丁香为原料合成的绿色氧化锌NPs具有较好的抑菌效果,具有广阔的抗菌潜力。同时,抗糖尿病活性表现出良好的抑制率,可作为纳米医学治疗糖尿病的有效药物。
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Anti-diabetic and anti-microbial activity of aspalathus linearis and syzygium aromaticum formulation mediated zinc oxide nanoparticles.

Introduction: Zinc oxide nanoparticles (ZnO NPs) exhibit a wide range of biomedical applications majorly used as antiinflammatory, anti-cancer, anti-diabetic, and anti-microbial activity and other biomedical applications because they show less toxicity and are very compatible. Zinc metal is an inorganic and essential element in the human body at the trace level. ZnO NPs are also GRAS substances (Generally Recognized As Safe). This study's main objective is synthesizing zinc oxide nanoparticles using red tea & clove mediated herbal formulation and screening for its antimicrobial, and anti-diabetic properties.

Materials and methods: Red tea and clove-mediated ZnO NPs were synthesized using the green synthesis method. The anti-microbial activity was tested against oral pathogens using the agar well diffusion method, while the anti-diabetic activity was estimated using the alpha-amylase inhibitory assay method by using red tea and clovemediated ZnO NPs.

Results: ZnO NPs were successfully synthesized using red tea and clove-formulated extract. The synthesized ZnO NPs using Aspalathus linearis (red tea) and Syzygium aromaticum (clove) mediated ZnO NPs were characterized using UV visible spectrophotometry and SEM (Scanning Electron Microscope) analysis. The green synthesized ZnO NPs show promising anti-microbial activity by exhibiting a 12 mm zone of inhibition against S. aureus, 11 mm in E. faecalis, 9 mm in S. mutans, and 11 mm in C. albicans. In anti-diabetic activity, the green synthesized ZnO NPs showed a maximum inhibition percentage of up to 80% at the maximum concentration of 50 µg/mL.

Conclusion: Green synthesized ZnO NPs using red tea and clove showed maximum efficacy in anti-microbial properties which can lead to huge potential use as antibacterial agents. Simultaneously, anti-diabetic activity showed an excellent inhibition percentage which can be a potent therapeutic agent in the field of nanomedicine in diabetes management.

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来源期刊
Medical Journal of Malaysia
Medical Journal of Malaysia Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
165
期刊介绍: Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.
期刊最新文献
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