Randy Randy, Khandar Yosua, Aswin Guntara, Nicko P Hardiansyah
{"title":"干细胞治疗椎间盘源性腰痛：系统综述。","authors":"Randy Randy, Khandar Yosua, Aswin Guntara, Nicko P Hardiansyah","doi":"10.14444/86717","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Low back pain (LBP) is 1 of the most common problems that present in 80% of people. LBP can be caused by some pathologies, with discogenic pain being 1 source. Pain from LBP can become chronic and also cause disability. Treatment options for LBP varied from conservative to operative, and a novel treatment nowadays is using stem cells therapy to treat with pain from LBP.</p><p><strong>Methods: </strong>Database searches from Pubmed and ScienceDirect from inception to 13 September 2023. A total of 283 discogenic LBP cases from 8 articles. This study measured clinical outcomes using a visual analog scale (VAS) and Oswestry Disability Index (ODI) obtained from each study.</p><p><strong>Results: </strong>Functional outcomes in patients treated with stem cell therapy showed significant improvement ODI and VAS (<i>P</i> < 0.00001). Improvement also showed in Pfirrmann grade before and after treatment with stem cells (<i>P</i> = 0.005). Subgroup analyses using bone marrow aspirate concentrate also showed significant differences in both ODI and VAS (<i>P</i> < 0.00001).</p><p><strong>Conclusion: </strong>Stem cells therapy could be beneficial as an option of treatment for discogenic LBP in improving pain and activity of daily living.</p><p><strong>Clinical relevance: </strong>Intradiscal stem cell therapy is a promising alternative for managing discogenic low back pain, offering improvements in pain and function.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stem Cells Therapy as a Treatment for Discogenic Low Back Pain: A Systematic Review.\",\"authors\":\"Randy Randy, Khandar Yosua, Aswin Guntara, Nicko P Hardiansyah\",\"doi\":\"10.14444/86717\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Low back pain (LBP) is 1 of the most common problems that present in 80% of people. LBP can be caused by some pathologies, with discogenic pain being 1 source. Pain from LBP can become chronic and also cause disability. Treatment options for LBP varied from conservative to operative, and a novel treatment nowadays is using stem cells therapy to treat with pain from LBP.</p><p><strong>Methods: </strong>Database searches from Pubmed and ScienceDirect from inception to 13 September 2023. A total of 283 discogenic LBP cases from 8 articles. This study measured clinical outcomes using a visual analog scale (VAS) and Oswestry Disability Index (ODI) obtained from each study.</p><p><strong>Results: </strong>Functional outcomes in patients treated with stem cell therapy showed significant improvement ODI and VAS (<i>P</i> < 0.00001). Improvement also showed in Pfirrmann grade before and after treatment with stem cells (<i>P</i> = 0.005). Subgroup analyses using bone marrow aspirate concentrate also showed significant differences in both ODI and VAS (<i>P</i> < 0.00001).</p><p><strong>Conclusion: </strong>Stem cells therapy could be beneficial as an option of treatment for discogenic LBP in improving pain and activity of daily living.</p><p><strong>Clinical relevance: </strong>Intradiscal stem cell therapy is a promising alternative for managing discogenic low back pain, offering improvements in pain and function.</p><p><strong>Level of evidence: 4: </strong></p>\",\"PeriodicalId\":38486,\"journal\":{\"name\":\"International Journal of Spine Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Spine Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14444/86717\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Spine Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14444/86717","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Stem Cells Therapy as a Treatment for Discogenic Low Back Pain: A Systematic Review.
Background: Low back pain (LBP) is 1 of the most common problems that present in 80% of people. LBP can be caused by some pathologies, with discogenic pain being 1 source. Pain from LBP can become chronic and also cause disability. Treatment options for LBP varied from conservative to operative, and a novel treatment nowadays is using stem cells therapy to treat with pain from LBP.
Methods: Database searches from Pubmed and ScienceDirect from inception to 13 September 2023. A total of 283 discogenic LBP cases from 8 articles. This study measured clinical outcomes using a visual analog scale (VAS) and Oswestry Disability Index (ODI) obtained from each study.
Results: Functional outcomes in patients treated with stem cell therapy showed significant improvement ODI and VAS (P < 0.00001). Improvement also showed in Pfirrmann grade before and after treatment with stem cells (P = 0.005). Subgroup analyses using bone marrow aspirate concentrate also showed significant differences in both ODI and VAS (P < 0.00001).
Conclusion: Stem cells therapy could be beneficial as an option of treatment for discogenic LBP in improving pain and activity of daily living.
Clinical relevance: Intradiscal stem cell therapy is a promising alternative for managing discogenic low back pain, offering improvements in pain and function.
期刊介绍：
The International Journal of Spine Surgery is the official scientific journal of ISASS, the International Intradiscal Therapy Society, the Pittsburgh Spine Summit, and the Büttner-Janz Spinefoundation, and is an official partner of the Southern Neurosurgical Society. The goal of the International Journal of Spine Surgery is to promote and disseminate online the most up-to-date scientific and clinical research into innovations in motion preservation and new spinal surgery technology, including basic science, biologics, and tissue engineering. The Journal is dedicated to educating spine surgeons worldwide by reporting on the scientific basis, indications, surgical techniques, complications, outcomes, and follow-up data for promising spinal procedures.
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