Penetrating orbital trauma: Comprehensive review and meta-analysis of bullet injuries.

Background: Orbital bullet injuries resulting from high-velocity trauma pose significant clinical challenges due to the potential for severe ocular and systemic complications. This meta-analysis consolidates the existing body of knowledge on direct orbital bullet injuries with respect to clinical outcomes, management strategies, and long-term effects.

Methods: The literature search was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using databases such as PubMed and Scopus. Seventeen articles were reviewed, out of which six studies met the inclusion criteria. Extracted data included details on study design, sample size, patient demographics, projectile type, clinical presentation, imaging modalities used in establishing the diagnosis, surgical interventions performed, duration of follow-up, and the outcomes achieved. Data synthesis was done using fixed and random effects models; heterogeneity testing was assessed using the I² statistic.

Results: A total of 688 patients with orbital bullet injuries were analyzed. The average age years ranged from 7 to 58, with a predilection for the male gender, about 70%. These injuries caused marked visual impairment, which included optic nerve injuries, legal blindness, cornea injuries, hyphema, orbital fractures, vitreous hemorrhage, lid lacerations, cataracts, and retinal injuries. Optic nerve injuries exhibited substantial variability (I² = 100%, H² = 1.254 × 10⁸). Legal blindness was common (I² = 100%, H² = 1.628 × 10⁷), with high rates reported in conflict zones. Corneal injuries and hyphema were also prevalent, with significant heterogeneity observed (I² = 100%, H² = 8.183 × 10⁶ for corneal injuries and I² = 99.861%, H² = 721.638 for hyphema). Only orbital fractures, vitreous hemorrhage, lid lacerations, cataracts, and retinal injuries showed very high heterogeneity with varying clinical presentation. Early surgical intervention and advanced imaging techniques played a very vital role in the management of these injuries and those which improved the prognosis of outcome.

Conclusion: Orbital bullet injuries remain a great clinical challenge and are very variable in nature. This huge variability of injury patterns and outcomes enjoins that treatment must be individualized, with very early intervention, evolved imaging modalities, and thorough surgical management for the best possible improvement in the patient's outcomes and prevention of long-term sequelae. Further studies should be done to come up with unified guidelines regarding the evaluation and treatment of such complex injuries.