{"title":"多能合成细胞的模拟分化","authors":"","doi":"10.1038/s41557-024-01684-w","DOIUrl":null,"url":null,"abstract":"An essential feature of pluripotent synthetic cells is that they must become desensitized to certain differentiation signals that are received after their initial response and commitment to a specific fate. This progression enables a pluripotent synthetic cell to specialize first into a multipotent cell and ultimately into a terminally differentiated cell.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"36 1","pages":""},"PeriodicalIF":19.2000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mimicking of differentiation in pluripotent synthetic cells\",\"authors\":\"\",\"doi\":\"10.1038/s41557-024-01684-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An essential feature of pluripotent synthetic cells is that they must become desensitized to certain differentiation signals that are received after their initial response and commitment to a specific fate. This progression enables a pluripotent synthetic cell to specialize first into a multipotent cell and ultimately into a terminally differentiated cell.\",\"PeriodicalId\":18909,\"journal\":{\"name\":\"Nature chemistry\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":19.2000,\"publicationDate\":\"2025-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1038/s41557-024-01684-w\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1038/s41557-024-01684-w","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Mimicking of differentiation in pluripotent synthetic cells
An essential feature of pluripotent synthetic cells is that they must become desensitized to certain differentiation signals that are received after their initial response and commitment to a specific fate. This progression enables a pluripotent synthetic cell to specialize first into a multipotent cell and ultimately into a terminally differentiated cell.
期刊介绍：
Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry.
The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry.
Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry.
Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests.
Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.
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