Benjamin T. Manard , Veronica C. Bradley , Lyndsey Hendriks , Daniel R. Dunlap , N. Alex Zirakparvar , Brian W. Ticknor , Miguel Toro-Gonzalez , Hunter B. Andrews
{"title":"单粒子MC-ICP-MS分析纳米Nd的同位素：与单粒子icp - tof - ms的比较研究。","authors":"Benjamin T. Manard , Veronica C. Bradley , Lyndsey Hendriks , Daniel R. Dunlap , N. Alex Zirakparvar , Brian W. Ticknor , Miguel Toro-Gonzalez , Hunter B. Andrews","doi":"10.1016/j.talanta.2025.127516","DOIUrl":null,"url":null,"abstract":"<div><div>Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO<sub>4</sub>) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R<sup>2</sup> between 0.98 and 0.99) compared to ICP-TOF-MS (R<sup>2</sup> between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the <sup>142</sup>Nd/<sup>144</sup>Nd, <sup>143</sup>Nd/<sup>144</sup>Nd, <sup>145</sup>Nd/<sup>14</sup><sup>4</sup>Nd, <sup>146</sup>Nd/<sup>144</sup>Nd, and <sup>148</sup>Nd/<sup>144</sup>Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"286 ","pages":"Article 127516"},"PeriodicalIF":6.1000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single particle-ICP-TOF-MS\",\"authors\":\"Benjamin T. Manard , Veronica C. Bradley , Lyndsey Hendriks , Daniel R. Dunlap , N. Alex Zirakparvar , Brian W. Ticknor , Miguel Toro-Gonzalez , Hunter B. Andrews\",\"doi\":\"10.1016/j.talanta.2025.127516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO<sub>4</sub>) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R<sup>2</sup> between 0.98 and 0.99) compared to ICP-TOF-MS (R<sup>2</sup> between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the <sup>142</sup>Nd/<sup>144</sup>Nd, <sup>143</sup>Nd/<sup>144</sup>Nd, <sup>145</sup>Nd/<sup>14</sup><sup>4</sup>Nd, <sup>146</sup>Nd/<sup>144</sup>Nd, and <sup>148</sup>Nd/<sup>144</sup>Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.</div></div>\",\"PeriodicalId\":435,\"journal\":{\"name\":\"Talanta\",\"volume\":\"286 \",\"pages\":\"Article 127516\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Talanta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0039914025000025\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039914025000025","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single particle-ICP-TOF-MS
Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO4) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R2 between 0.98 and 0.99) compared to ICP-TOF-MS (R2 between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the 142Nd/144Nd, 143Nd/144Nd, 145Nd/144Nd, 146Nd/144Nd, and 148Nd/144Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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