Shitong Mao, Jihong Wang, Holly McMillan, Abdallah Sherif Radwan Mohamed, Sheila Buoy, Sara Ahmed, Samuel L Mulder, Mohamed A Naser, Renjie He, Kareem A Wahid, Melissa Mei Chen, Yao Ding, Amy C Moreno, Stephen Y Lai, Clifton David Fuller, Katherine Arnold Hutcheson
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引用次数: 0
摘要
背景：头颈部淋巴水肿和纤维化（HN-LEF）的量化在头颈部癌（HNC）治疗后遗症的调查和管理中至关重要。方法：通过物理/触觉检查（No-LEF, a - b =水肿，C =水肿+纤维化，D =纤维化），检查T1和t2加权MRI信号强度（SI）与HN-LEF类别的关系，并检查MRI结构体积与口腔内和颏下区域新颖的10分HN-LEF评分的关系。结果：我们确定了与MRI SI相关的HN-LEF类别之间的排名差异（T2 SI的A-B和C高于D和No-LEF， T1的A-B最高）。此外，MRI上的6对FOM体积显示出强烈的负相关(p)。结论：MRI SI和结构体积都可能是HNC患者软组织水肿状态的成像生物标志物。
Exploring Quantitative MRI Biomarkers of Head and Neck Post-Radiation Lymphedema and Fibrosis: Post Hoc Analysis of a Prospective Trial.
Background: Quantifying head and neck lymphedema and fibrosis (HN-LEF) is crucial in the investigation and management of treatment sequelae in head and neck cancer (HNC).
Methods: The T1- and T2-weighted MRI signal intensity (SI) was examined in relation to HN-LEF categories per physical/tactile examination (No-LEF, A-B = edema, C = edema + fibrosis, D = fibrosis), and MRI structural volumes were examined in relation to a novel 10-point HN-LEF score in the intraoral and submental regions.
Results: We identified differences in ranks among HN-LEF categories in relation to the MRI SI (A-B and C are higher than D and No-LEF for T2 SI, and A-B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (p < 0.05) with the HN-LEF score at adjacent palpable sites.
Conclusion: Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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