液相色谱- q -精确轨道阱质谱结合GNPS分子网络分析青霉菌粗提物化学成分

IF 1.8 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS Rapid Communications in Mass Spectrometry Pub Date : 2025-01-12 DOI:10.1002/rcm.9984

Ya Lu, Jiao Yang, Kun Ma, Jiahui Qi, Jessica Villegas-Moreno

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引用次数: 0

摘要

在培养条件下，采用液相色谱- Q-Exactive Orbitrap质谱结合全球天然产物社交网络（GNPS）技术对一株中国产真菌青霉菌（Penicillium chrysogenum）进行分析，快速鉴定出20种次级代谢物。其中有8种聚酮类、2种邻苯酞类、6种双酮哌嗪类生物碱等。研究并提出了一种新的天然产物的候选网络。

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Analysis of Chemical Components of Penicillium chrysogenum Crude Extract Using Liquid Chromatography Coupled With Q-Exactive Orbitrap Mass Spectrometry Combined With GNPS Molecular Networking

A Chinese isolate of the fungus Penicillium chrysogenum was analyzed using liquid chromatography coupled with Q-Exactive Orbitrap mass spectrometry combined with Global Natural Products Social Networking (GNPS) on culture condition leading to the rapid identification of 20 secondary metabolites. Among them are eight polyketones, two phthalides, six diketopiperazine alkaloids, and others. A meleagrine network was examined and proposed as a promising candidate for new natural products.

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来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.