髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）作为新发难治性癫痫持续状态（NORSE）的原因：病例报告和文献回顾

IF 2.9 4区医学 Q3 IMMUNOLOGY Journal of neuroimmunology Pub Date : 2025-01-08 DOI:10.1016/j.jneuroim.2025.578522

Abhishek Vaingankar, Ayush Agarwal, Divyani Garg, Pranjal Gupta, Ajay Garg, Divya M Radhakrishnan, Awadh K Pandit, Achal Kumar Srivastava

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引用次数: 0

摘要

髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）是一种罕见的NORSE病因。我们描述了一名年轻女孩的病例，她出现了与MOGAD相关的NORSE，并对迄今为止与MOGAD相关的所有NORSE病例进行了系统回顾。与MOGAD相关的癫痫发作通常具有良好的预后，但偶尔也可能是灾难性的，对常规治疗无反应。早期开始抗il - 6治疗可能有助于改善这类患者的预后。

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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as a cause of new-onset refractory status epilepticus (NORSE): Case report and review of literature.

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare cause of NORSE. We describe the case of a young girl who presented with NORSE associated with MOGAD along with a systematic review of all cases of NORSE associated with MOGAD till date. Seizures associated with MOGAD are usually associated with good outcome but can occasionally be catastrophic and non-responsive to conventional therapies. Early initiation of anti-IL6 therapies might help improve outcomes in such patients.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.