Recent advances in enantioselective construction of C–N bonds involving radical intermediates

This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates. Enantioselective radical amination strategies have proven to be highly effective for synthesizing chiral amines and nitrogen-containing heterocycles. Significant progress has been made in the enantioselective installation of N-containing groups into halogenated alkanes, olefins, and dienes with the asymmetric formation of C–N bonds as the key step via diverse pathways including reductive elimination, radical-polar crossover, amino group substitution, radical–radical cross-coupling, etc. This review highlights these recent developments and the mechanistic insights that drive these transformations.