二氧化硅纳米颗粒:一种有前途的抗癌药物递送载体

IF 3.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY AAPS PharmSciTech Pub Date : 2025-01-13 DOI:10.1208/s12249-024-02982-9
T. Naga Aparna, Rohit Kumar, Shah Raj Ali, Dhaval J. Patel, Kazi Julekha, Touseef Begum, Jyoti Bala, Pawan Kumar
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引用次数: 0

摘要

在过去的几十年里,癌症的发病率和死亡率一直在上升,在不牺牲健康细胞的情况下消灭肿瘤细胞仍然是一项艰巨的任务。由于药物分子的特异性和溶解度较低,患者往往需要高剂量才能达到预期的治疗效果。二氧化硅纳米颗粒(SiNPs)可以有效地将治疗剂输送到体内的目标部位,从而解决了这些挑战。由于其独特的结构特性、生物相容性和多功能性,使用sinp作为抗癌药物递送的载体已成为一种有前途的策略。本文综述了SiNPs在癌症治疗中的各个方面,重点介绍了它们的合成、功能化以及在传递化疗药物、光敏剂和核酸方面的应用。sinp具有载药能力强、释放可控、靶向给药、提高治疗效果、降低全身毒性等优点。此外,本综述旨在深入了解SiNPs在革新癌症治疗和改善患者预后方面的现状和前景。图形抽象
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Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges. Using SiNPs as vehicles for anti-cancer drug delivery has emerged as a promising strategy due to their unique structural properties, biocompatibility, and versatility. This review explores the various aspects of SiNPs in cancer therapy, highlighting their synthesis, functionalization, and application in delivering chemotherapeutic agents, photosensitizers, and nucleic acids. SiNPs offer advantages such as high drug loading capacity, controlled release, and targeted delivery, enhancing therapeutic efficacy and reducing systemic toxicity. Moreover, this review aims to provide an in-depth understanding of the current state and prospects of SiNPs in revolutionizing cancer treatment and improving patient outcomes.

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来源期刊
AAPS PharmSciTech
AAPS PharmSciTech 医学-药学
CiteScore
6.80
自引率
3.00%
发文量
264
审稿时长
2.4 months
期刊介绍: AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
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