I V Kologrivova, A A Dmitriukov, N V Naryzhnaya, E S Kravchenko, O A Kharitonova, A I Vyrostkova, A S Krapivina, S L Andreev, O A Koshelskaya, T E Suslova
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引用次数: 0
摘要
研究42例慢性冠心病（CHD）患者心外膜（EAT）和胸腺（TAT）脂肪组织基质血管部分（SVF）细胞FoxP3+ t -调节性（Treg）淋巴细胞及细胞因子的产生。在Gensini评分(GS)≥74（动脉粥样硬化最严重）的TAT SVF中，IL-1β、TNF、IL-4和IFNγ的产生较高，而FoxP3核易位低于GShiFoxP3+Treg患者，TAT中FoxP3核易位与TAT中IFNγ的产生负相关，与EAT中IL-4的产生直接相关。结果提示冠状动脉粥样硬化的严重程度与EAT和TAT的SVF细胞产生细胞因子的能力和FoxP3+Treg淋巴细胞的特性有关。
Production of the Key Immunoregulatory Cytokines and the Content of FoxP3+ T-Regulatory Lymphocytes in the Epicardial and Thymus Adipose Tissue in Patients with Coronary Heart Disease.
FoxP3+ T-regulatory (Treg) lymphocytes and cytokine production by cells from the stromal vascular fraction (SVF) of epicardial (EAT) and thymus (TAT) adipose tissue of 42 patients with chronic coronary heart disease (CHD) were studied. In the SVF of TAT in patients with Gensini Score (GS)≥74 (the most severe atherosclerosis), the production of IL-1β, TNF, IL-4, and IFNγ was higher, while FoxP3 translocation into the nucleus was lower than in patients with GS<74. The GS index directly correlated with the production of IL-4, IL-1β, and TNF by cells of the SVF of TAT, and inversely - with the production of TNF, IL-17, and IL-10 by cells of the SVF of EAT. The proportion of CD25hiFoxP3+Treg with FoxP3 nuclear translocation in TAT inversely correlated with IFNγ production in TAT and directly correlated with IL-4 production in EAT. The results obtained suggest that the severity of coronary atherosclerosis is interrelated with the ability of SVF cells of EAT and TAT to produce cytokines and the properties of FoxP3+Treg lymphocytes.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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