Jae-Min Park, Ja-Eun Choi, Ji-Won Lee, Kyung-Won Hong
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引用次数: 0
摘要
戒烟受遗传和环境因素的影响,尤其是影响尼古丁代谢的遗传多态性。本研究调查了韩国男性尼古丁代谢相关基因变异与戒烟之间的关系。方法:针对尼古丁代谢相关基因的单核苷酸多态性(snp)进行候选基因关联研究。参与者被分为从不吸烟者、曾经吸烟者和现在吸烟者。使用显著snp计算遗传风险评分(GRS)来评估累积遗传影响。结果:6个snp在韩国队列中显示与戒烟显著相关。较高的GRS与当前吸烟的几率比以前吸烟的几率增加相关(OR = 1.18, 95% CI: 1.12-1.25, P < 0.001)。结论:这项研究表明了戒烟的重要遗传因素,强调了针对特定人群的方法的重要性,并可能有助于基于韩国人遗传易感性的个性化戒烟策略。
Nicotine Metabolism-Related Genetic Polymorphisms Associated with Smoking Cessation in Korean Men: A Candidate Gene Association Study in a Korean Cohort.
Introduction: Smoking cessation is influenced by genetic and environmental factors, particularly genetic polymorphisms influencing nicotine metabolism. This study investigated the association between specific nicotine metabolism-related genetic variants and smoking cessation among Korean men.
Methods: A candidate gene association study was performed targeting single nucleotide polymorphisms (SNPs) within nicotine metabolism-related genes. Participants were categorized as never, former, or current smokers. A Genetic Risk Score (GRS) was computed using significant SNPs to evaluate cumulative genetic influence.
Results: Six SNPs showed significant association with smoking cessation in a Korean cohort. A higher GRS was associated with increased odds of current smoking compared to former smoking (OR = 1.18, 95% CI: 1.12-1.25, P < 0.001).
Conclusion: This study indicates a substantial genetic component in smoking cessation, highlighting the importance of population-specific approaches, and may aid personalized smoking cessation strategies based on genetic predisposition among Koreans.
期刊介绍:
Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.