微塑料和纳米塑料对心血管系统线粒体功能的影响:当前文献综述。

IF 1.9 4区 医学 Q3 PHYSIOLOGY Physiological research Pub Date : 2024-12-31 DOI:10.33549/physiolres.935500
T Lerchner, J Jedlička, M Kripnerová, J Dejmek, J Kuncová
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引用次数: 0

摘要

线粒体是关键的细胞器,具有多方面的功能,包括细胞呼吸、代谢过程、钙转换和细胞凋亡的调节,主要通过产生活性氧(ROS)。线粒体动力学的扰动与许多心血管疾病(如心力衰竭、缺血性心脏病和各种心肌病)的病因有着复杂的联系。值得注意的是,最近的注意力集中在微和纳米塑料污染对线粒体完整性的有害影响上,这一领域缺乏全面的研究。鉴于塑料颗粒污染的日益普遍,以及老龄化人群中心血管疾病的伴随负担,了解心血管系统内线粒体与微纳米塑料污染之间的相互作用具有至关重要的意义。这篇综述试图阐明目前对这种复杂相互作用的理解,尽管理解有限。关键词线粒体,纳米塑料,微塑料,心血管系统,内皮功能,氧化磷酸化
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Influence of micro- and nanoplastics on mitochondrial function in the cardiovascular system: a review of the current literature.

Mitochondria represent pivotal cellular organelles endowed with multifaceted functionalities encompassing cellular respiration, metabolic processes, calcium turnover, and the regulation of apoptosis, primarily through the generation of reactive oxygen species (ROS). Perturbations in mitochondrial dynamics have been intricately linked to the etiology of numerous cardiovascular pathologies, such as heart failure, ischemic heart disease, and various cardiomyopathies. Notably, recent attention has been directed towards the detrimental impact of micro- and nanoplastic pollution on mitochondrial integrity, an area underscored by a paucity of comprehensive investigations. Given the escalating prevalence of plastic particle contamination and the concomitant burden of cardiovascular disease in aging populations, understanding the interplay between mitochondria within the cardiovascular system and micro- and nanoplastic pollution assumes paramount importance. This review endeavors to elucidate the current albeit limited comprehension surrounding this complex interplay. Key words Mitochondria, Nanoplastics, Microplastics, Cardiovascular system, Endothelial function, Oxidative phosphorylation.

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来源期刊
Physiological research
Physiological research 医学-生理学
CiteScore
4.00
自引率
4.80%
发文量
108
审稿时长
3 months
期刊介绍: Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.
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