ninurin1和雌激素在AOM/ dss诱导的雄性小鼠结肠炎相关结直肠癌中的作用

IF 4.1 2区 医学 Q2 ONCOLOGY Cancer Research and Treatment Pub Date : 2025-01-13 DOI:10.4143/crt.2024.959
Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Eun Hye Kim, Sungchan Ha, Eun Shin, Ha-Na Lee, Hoon Choi, Kyu-Won Kim, Sejin Jeon, Goo Taeg Oh
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引用次数: 0

摘要

目的:Ninjury-induced protein 1 (Ninjury-induced protein 1,简称Ninj1)与炎症和肿瘤进展有关,并在多种癌症中表达增加。本研究旨在通过其与17β-雌二醇(E2)的相互作用,探讨Ninj1在结肠炎相关结直肠癌(CRC)中的作用。材料和方法:采用偶氮氧甲烷(AOM)/葡聚糖硫酸钠(DSS)小鼠结肠炎相关结直肠癌模型,将野生型(WT)和敲除Ninj1 (KO)的雄性小鼠分别给予或不给予E2。结果:在第2周,经AOM/DSS治疗后,Ninj1 KO小鼠结肠炎症状比WT小鼠减轻。E2给药可显著缓解WT和Ninj1 KO小鼠的这些症状,降低疾病活动指数(DAI)、结肠长度缩短和组织病理学损伤。E2治疗降低了两组促炎介质的水平,其中Ninj1 KO组表现出更明显的反应。在第13周,Ninj1 KO小鼠的肿瘤发展明显低于WT小鼠,特别是在远端结肠。E2处理抑制WT小鼠肿瘤形成,对Ninj1 KO小鼠远端结肠肿瘤发生有较强的抑制作用。E2也能调节WT小鼠的免疫细胞群,包括巨噬细胞群和T细胞群;然而,这些影响在Ninj1 KO小鼠中减弱。结论:这些研究结果提示,Ninj1在调节结肠炎和结直肠癌进展中发挥作用,E2发挥抗炎和抗肿瘤作用受Ninj1状态的影响。
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The Roles of Ninjurin1 and Estrogen in Modulating AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Male Mice.

Purpose: Ninjury-induced protein 1 (Ninj1) is associated with inflammation and tumor progression and shows increased expression in various cancers. This study aimed to investigate the role of Ninj1 in colitis-associated colorectal cancer (CRC) by focusing on its interaction with 17β-estradiol (E2).

Materials and methods: Using an azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse model of colitis-associated CRC, wild-type (WT) and Ninj1 knockout (KO) male mice were treated with or without E2.

Results: At week 2, Ninj1 KO mice exhibited attenuated colitis symptoms than WT mice following AOM/DSS treatment. E2 administration significantly alleviated these symptoms in both WT and Ninj1 KO mice, with reductions in the disease activity index (DAI), colon length shortening, and histopathological damage. The levels of pro-inflammatory mediators were reduced by E2 treatment in both groups, with the Ninj1 KO group showing a more pronounced response. At week 13, tumor development in Ninj1 KO mice was significantly lower than that in WT mice, particularly in the distal colon. E2 treatment inhibited tumor formation in WT mice and had a stronger inhibitory effect on distal colon tumorigenesis in Ninj1 KO mice. Immune cell populations, including the populations of macrophages and T cells, were also modulated by E2 in WT mice; however, these effects were diminished in Ninj1 KO mice.

Conclusion: These findings suggest that Ninj1 plays a role in modulating colitis and CRC progression, with E2 exerting anti-inflammatory and anti-tumorigenic effects that are influenced by Ninj1 status.

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来源期刊
CiteScore
8.00
自引率
2.20%
发文量
126
审稿时长
>12 weeks
期刊介绍: Cancer Research and Treatment is a peer-reviewed open access publication of the Korean Cancer Association. It is published quarterly, one volume per year. Abbreviated title is Cancer Res Treat. It accepts manuscripts relevant to experimental and clinical cancer research. Subjects include carcinogenesis, tumor biology, molecular oncology, cancer genetics, tumor immunology, epidemiology, predictive markers and cancer prevention, pathology, cancer diagnosis, screening and therapies including chemotherapy, surgery, radiation therapy, immunotherapy, gene therapy, multimodality treatment and palliative care.
期刊最新文献
Lipid Metabolism Related Gene ACSL3 as a Biomarker for Predicting Immunotherapy Outcomes in Lung Adenocarcinoma. Prognostic Value of POST-Treatment Extent of Tumor (POSTTEXT) System in Patients with Hepatoblastoma. The Roles of Ninjurin1 and Estrogen in Modulating AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Male Mice. Clinical Characteristics of and Treatment Pattern for EGFR-Amplified Colorectal Cancer. Factors Associated with Smoking Cessation of Participants in the National Lung Cancer Screening Program in Korea.
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