Pulak R. Manna , Shengping Yang , P. Hemachandra Reddy
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Transcriptomic analysis reveals suppression of steroidogenic acute regulatory protein in gender-specific differences in Alzheimer's disease
Alzheimer's disease (AD)-related dementia preferentially impacts two-thirds of women and one-third of men.
The steroidogenic acute regulatory (StAR) protein mediates the biosynthesis of neurosteroids that sustain diverse neuronal activities.
Aging, involving neurosteroidal imbalance, is the predominant risk factor for AD causing dementia.
Transcriptomic analysis, including clinical cognitive diagnosis (cogdx) stages, displays marked attenuation of StAR in brains of AD women than those of AD men, compared with cognitively normal (Non-AD) subjects.
The present data provide the first evidence and new insights into the mechanism exemplifying the suppression of StAR in gender-specific differences in AD.
期刊介绍：
BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.
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