P A Kosmidis, N Uzunoglou, J Elemenoglou, S Kottaridis
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引用次数: 0
摘要
本实验研究的目的是评估热疗(HPT)和甲氨蝶呤(MTX)对移植Walker肉瘤Wistar大鼠可能的协同作用。HPT是由432 MHZ频率的微波通过2 x 5.5 cm2表面的源发射而产生的。肿瘤内温度维持在43摄氏度，由连接电子温度计的肿瘤内热电偶控制。进行了三个实验。首先，5只大鼠只应用HPT, 1只大鼠作为对照。第二组6只大鼠给予HPT和MTX联合用药。第三，给6只大鼠单独给予甲氨蝶呤。在第一个实验中，与对照组相比，所有5只老鼠的肿瘤都缩小了50%。在第二个实验中，肿瘤完全消失，在第三个实验中，肿瘤增大了。组织学上，在反应性肿瘤中可见广泛的坏死和血栓形成的血管。我们认为HPT和MTX在治疗Wistar大鼠Walker肉瘤中具有协同作用。
Combination of hyperthermia and methotrexate in the treatment of transplanted Walker sarcoma.
The purpose of this experimental study was to evaluate the possible synergistic effect of hyperthermia (HPT) and methotrexate (MTX) in Wistar rats transplanted with Walker sarcoma. HPT was induced by microwaves of 432 MHZ frequency transmitted through a source of 2 x 5.5 cm2 surface. The temperature in the tumor was maintained at 43 degrees C which was controlled by an intratumor thermocouple connected with an electronic thermometer. Three experiments were performed. First, in 5 rats HPT only was applied and one rat was used as control. Second, HPT and MTX in combination were given to 6 rats. Third, MTX alone was given to 6 rats. In the first experiment all 5 rats had 50% reduction of their tumors compared to control. In the second experiment complete disappearance of the tumor was noticed and in the third experiment the tumor increased in size. Histologically, in the responding tumors extensive necrosis was seen with thrombosed vessels. We conclude that HPT and MTX are synergistic in treating Walker sarcoma in Wistar rats.
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