Chen Yang, Lei Yu, Jia Wang, Xiaokun Wang, Yuhan Yang, Ni He, Shijing Zhang, Hao Tang, Chen Dan Zou
{"title":"毛囊间充质干细胞诱导短暂性脑卒中后神经再生和修复。","authors":"Chen Yang, Lei Yu, Jia Wang, Xiaokun Wang, Yuhan Yang, Ni He, Shijing Zhang, Hao Tang, Chen Dan Zou","doi":"10.1159/000543261","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of hair follicle mesenchymal stem cells (HFMSCs) in ischemic stroke. Materials & methods: Rat transient ischemic stroke model was established to verify the effect of HFMSC transplantation. Behavioral experiment and TTC staining were used to estimate neurological outcome after HFMSC therapy. Pathological experiments were used to investigate the therapeutic roles of HFMSCs.</p><p><strong>Results: </strong>HFMSCs inhibited neural apoptosis and promoted neural proliferation. The number of neural cells around ischemic core increased after HFMSC transplantation. Besides, the grafted HFMSCs expressed neuron-specific marker in the penumbra. Finally, HFMSCs diminished infarct area and improved neurological scores.</p><p><strong>Conclusion: </strong>HFMSCs can improve neurological outcome via anti-apoptosis and promoting neural stem cells proliferation, indicating their therapeutic potential in ischemic stroke.</p>","PeriodicalId":9683,"journal":{"name":"Cerebrovascular Diseases","volume":" ","pages":"1-21"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hair Follicle Mesenchymal Stem Cells Induce Neural Regeneration and Repair after Transient Ischemic Stroke.\",\"authors\":\"Chen Yang, Lei Yu, Jia Wang, Xiaokun Wang, Yuhan Yang, Ni He, Shijing Zhang, Hao Tang, Chen Dan Zou\",\"doi\":\"10.1159/000543261\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To investigate the effect of hair follicle mesenchymal stem cells (HFMSCs) in ischemic stroke. Materials & methods: Rat transient ischemic stroke model was established to verify the effect of HFMSC transplantation. Behavioral experiment and TTC staining were used to estimate neurological outcome after HFMSC therapy. Pathological experiments were used to investigate the therapeutic roles of HFMSCs.</p><p><strong>Results: </strong>HFMSCs inhibited neural apoptosis and promoted neural proliferation. The number of neural cells around ischemic core increased after HFMSC transplantation. Besides, the grafted HFMSCs expressed neuron-specific marker in the penumbra. Finally, HFMSCs diminished infarct area and improved neurological scores.</p><p><strong>Conclusion: </strong>HFMSCs can improve neurological outcome via anti-apoptosis and promoting neural stem cells proliferation, indicating their therapeutic potential in ischemic stroke.</p>\",\"PeriodicalId\":9683,\"journal\":{\"name\":\"Cerebrovascular Diseases\",\"volume\":\" \",\"pages\":\"1-21\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cerebrovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000543261\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebrovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000543261","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Hair Follicle Mesenchymal Stem Cells Induce Neural Regeneration and Repair after Transient Ischemic Stroke.
Aim: To investigate the effect of hair follicle mesenchymal stem cells (HFMSCs) in ischemic stroke. Materials & methods: Rat transient ischemic stroke model was established to verify the effect of HFMSC transplantation. Behavioral experiment and TTC staining were used to estimate neurological outcome after HFMSC therapy. Pathological experiments were used to investigate the therapeutic roles of HFMSCs.
Results: HFMSCs inhibited neural apoptosis and promoted neural proliferation. The number of neural cells around ischemic core increased after HFMSC transplantation. Besides, the grafted HFMSCs expressed neuron-specific marker in the penumbra. Finally, HFMSCs diminished infarct area and improved neurological scores.
Conclusion: HFMSCs can improve neurological outcome via anti-apoptosis and promoting neural stem cells proliferation, indicating their therapeutic potential in ischemic stroke.
期刊介绍：
A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.
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