降钙素原作为肝切除术后感染性并发症的早期预测指标。

IF 1.8 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Digestive Surgery Pub Date : 2025-01-17 DOI:10.1159/000543635

Haruki Mori, Hiromitsu Maehira, Nobuhito Nitta, Takeru Maekawa, Hajime Ishikawa, Katsushi Takebayashi, Sachiko Kaida, Toru Miyake, Masaji Tani

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引用次数: 0

摘要

前言：本研究旨在确定血清降钙素原（PCT）水平在预测肝切除术后感染中的临床价值。方法：回顾性分析301例肝切除术患者的病历资料。我们将患者分为感染阳性组和感染阴性组。我们研究了围手术期炎症标志物如c反应蛋白（CRP）和PCT水平的变化。评估感染并发症与围手术期炎症标志物之间的关系，以确定肝切除术后感染并发症的预测因素。结果：术后发生感染并发症67例（22.3%）。术后第1、3天PCT水平的曲线下面积（auc）分别为0.794、0.845，而CRP水平的曲线下面积（auc）分别为0.493、0.641。PCT水平预测pod1和pot3术后感染并发症的AUC优于CRP。多因素分析表明，pod 1和pod 3的PCT水平是肝切除术后感染并发症的独立预测因子。结论：PCT是肝切除术后感染性并发症的唯一预测指标，对POD 1型肝切除术后感染性并发症的检测具有重要价值。

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Procalcitonin as an early predictive marker for infectious complications after hepatectomy.

Introduction: The present study aimed to determine the clinical value of serum procalcitonin (PCT) level in predicting postoperative infections after hepatectomy.

Methods: Medical records of 301 consecutive patients who underwent hepatectomy were retrospectively reviewed. We divided the patients into infection-positive and infection-negative groups. We investigated the changes in perioperative inflammatory markers such as C-reactive protein level (CRP) and PCT level. Associations between infectious complications and perioperative inflammatory markers were evaluated to identify predictive factors of infectious complications after hepatectomy.

Results: Postoperative infectious complications occurred in 67 (22.3 %) patients. The areas under the curve (AUCs) using PCT levels on postoperative days (PODs) 1 and 3 were 0.794 and 0.845, respectively, whereas those using CRP were 0.493 and 0.641, respectively. PCT level had a better AUC than CRP for predicting postoperative infectious complications on PODs 1 and 3. Multivariate analysis indicated PCT levels on PODs 1 and 3 were an independent predictor of infectious complications after hepatectomy.

Conclusion: PCT is the only predictive marker for infectious complications after hepatectomy and is valuable for detecting infectious complications from POD 1.

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来源期刊

Digestive Surgery 医学-外科

CiteScore

4.90

自引率

3.70%

发文量

审稿时长

3 months

期刊介绍： ''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.