随机前庭电刺激改善青少年特发性脊柱侧凸在障碍协商过程中的动力学表现。

IF 1.7 4区 医学 Q4 NEUROSCIENCES Experimental Brain Research Pub Date : 2025-01-18 DOI:10.1007/s00221-024-06995-5
Haoyu Xie, Yan Li, Liping Zhao, Jung Hung Chien, Chuhuai Wang
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引用次数: 0

摘要

前庭功能障碍已被报道为青少年特发性脊柱侧凸(AIS)的潜在原因。然而,目前尚不清楚随机前庭电刺激(GVS)如何影响AIS患者的运动表现。本研究旨在探讨随机GVS对AIS患者越障过程中地面反作用力(GRF)测量的影响。15例AIS患者和15例年龄/性别匹配的健康对照(HC)参加了本研究。随机GVS通过放置在双侧乳突上的电极施加,强度为个人感觉阈值的80%。随机分配2种GVS(随机GVS/假刺激)和3种障碍条件(Level/Low/High) 6个步行试验,每个试验重复3次。采用4个AMTI测力板测量前后(AP1/AP2)、中外侧(ML1/ML2)和垂直(V1/V2)方向的GRF峰值和脉冲。AP1 (F2,56=3.537, p = 0.036)、V1 (F2,56=4.118, p = 0.021)、ML1 (F2,56=3.313, p = 0.044)和内侧-外侧脉冲(F2,56=4.386, p = 0.017)对台阶过障具有显著的相互作用。事后比较显示,与假刺激相比,随机GVS的应用显著(1)提高了两组患者的AP1 (Low: p = 0.038)和V1 (Low: p 1) (AIS患者的ps1和内侧外侧脉冲显著高于HC),表明随机GVS对AIS的ML1和内侧外侧脉冲的降低效果更大。随机GVS改善AIS患者越障时的运动表现,其潜在机制可能与诱导随机共振现象增强前庭知觉有关。我们的研究提供了随机GVS作为一种针对AIS患者前庭相关姿势不稳定的新方法。
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Stochastic galvanic vestibular stimulation improves kinetic performance in adolescent idiopathic scoliosis during obstacle negotiation.

Vestibular dysfunction has been reported as a potential cause in adolescent idiopathic scoliosis (AIS). However, it remained unclear how stochastic galvanic vestibular stimulation (GVS) affected kinetic performance of patients with AIS. This study aimed to investigate the effect of stochastic GVS on ground reaction forces (GRF) measures during obstacle negotiation among patients with AIS. Fifteen patients with AIS and 15 age/sex-matched healthy controls (HC) participated in this study. Stochastic GVS was applied via electrodes placed over bilateral mastoid process with the intensity of 80% of individual sensory thresholds. Six walking trials including 2 types of GVS (stochastic GVS/sham stimulation) and 3 obstacle conditions (Level/Low/High) were randomly allocated to each participant, and each trial was repeated 3 times. Four AMTI force plates were used to measure GRF peaks and impulses in anterior-posterior (AP1/AP2), medial-lateral (ML1/ML2), and vertical (V1/V2) directions. Significant interactions were observed in AP1 (F2,56=3.537, p = 0.036), V1 (F2,56=4.118, p = 0.021), ML1 (F2,56=3.313, p = 0.044) and medial-lateral impulses (F2,56=4.386, p = 0.017) for the step negotiating obstacles. Post-hoc comparisons showed that in comparison to sham stimulation, the application of stochastic GVS significantly (1) increased AP1 (Low: p = 0.038) and V1 (Low: p < 0.001; High: p = 0.035) in two groups; (2) decreased ML1 of two groups (AIS: ps < 0.01; HC: ps < 0.05) and medial-lateral impulses in patients with AIS (Low: p = 0.013; High: p = 0.015) during obstacle negotiation. Additionally, the rates of change in ML1 and medial-lateral impulses among patients with AIS were significantly higher than that of HC, indicating that stochastic GVS demonstrated a greater effect of decreasing ML1 and medial-lateral impulses in AIS. Stochastic GVS ameliorated kinetic performance of patients with AIS during obstacle negotiation, and its potential mechanism may involve the induction of stochastic resonance phenomenon to enhance vestibular perception. Our study offered stochastic GVS as a novel approach to target vestibular-related postural instability in AIS.

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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
228
审稿时长
1 months
期刊介绍: Founded in 1966, Experimental Brain Research publishes original contributions on many aspects of experimental research of the central and peripheral nervous system. The focus is on molecular, physiology, behavior, neurochemistry, developmental, cellular and molecular neurobiology, and experimental pathology relevant to general problems of cerebral function. The journal publishes original papers, reviews, and mini-reviews.
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