硬币的另一面:泛素特异性蛋白酶1在癌症进展和治疗中的蛋白质去泛素化。

IF 3.2 4区 医学 Q3 CHEMISTRY, MEDICINAL Future medicinal chemistry Pub Date : 2025-02-01 Epub Date: 2025-01-17 DOI:10.1080/17568919.2025.2453414
Xinlan Hu, Yan Wu, Mengmeng Yao, Zhuo Chen, Qianbin Li
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引用次数: 0

摘要

可逆蛋白泛素化是细胞内稳态的一个重要因素,泛素特异性蛋白酶1 (USP1)作为一个关键的去泛素化酶参与了癌症DNA损伤反应(DDR)和修复机制。虽然泛素连接酶已被广泛研究,但对泛素化的反向过程,特别是涉及USP1的机制的研究仍然相对有限。USP1在多种癌症中过表达,通过调节多种相关蛋白影响肿瘤的发生和进展。抑制USP1可有效抑制肿瘤的增殖和迁移,并可能有助于克服对顺铂和PARP抑制剂的耐药性。作为潜在的合成致死靶点,USP1具有重要的研究潜力。本文综述了USP1在癌症进展中的生物学机制、其调控的信号通路以及USP1抑制剂的最新进展,同时分析了针对USP1的机遇和挑战。通过采用“硬币的另一面”的观点,本综述旨在强调去泛素酶USP1的关键但经常被忽视的作用,将其与广泛研究的泛素连接酶进行对比,并强调其在癌症治疗中的治疗潜力。
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The other side of the coin: protein deubiquitination by Ubiquitin-Specific Protease 1 in cancer progression and therapy.

Reversible protein ubiquitination is a crucial factor in cellular homeostasis, with Ubiquitin-Specific Protease 1 (USP1) serving as a key deubiquitinase involved in DNA damage response (DDR) and repair mechanisms in cancer. While ubiquitin ligases have been extensively studied, research on the reverse process of ubiquitination, particularly the mechanisms involving USP1, remains relatively limited. USP1 is overexpressed in various cancers, influencing tumor initiation and progression by regulating multiple associated proteins. Inhibiting USP1 effectively suppresses tumor proliferation and migration and may help overcome resistance to cisplatin and PARP inhibitors. As a potential synthetic lethal target, USP1 demonstrates significant research potential. This review highlights the biological mechanisms of USP1 in cancer progression, the signaling pathways it regulates, and the latest advancements in USP1 inhibitors, while also analyzing the opportunities and challenges of targeting USP1. By adopting the perspective of "the other side of the coin," this review aims to underscore the crucial yet often overlooked role of the deubiquitinase USP1, contrasting it with the extensively studied ubiquitin ligases, and emphasizing its therapeutic potential in cancer treatment.

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来源期刊
Future medicinal chemistry
Future medicinal chemistry CHEMISTRY, MEDICINAL-
CiteScore
5.80
自引率
2.40%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.
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