{"title":"低浓度阿托品（0.01%）对中国近视儿童定量对比敏感度功能的影响。","authors":"Yu-Hao Ye, Yi-Yong Xian, Fang Liu, Zhong-Lin Lyu, Xing-Tao Zhou, Jing Zhao","doi":"10.18240/ijo.2025.01.14","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of 0.01% low-concentration atropine (LA) on quantitative contrast sensitivity function (qCSF) in children with myopia.</p><p><strong>Methods: </strong>This paired case-control study included 90 eyes of 58 children who were sex-, age-, and refraction-matched and equally divided into two groups: the 0.01% LA group had undergone 6mo use of daily 0.01% atropine and control group was naïve to LA. Routine ophthalmic examinations and qCSF test without refractive correction were performed. Two groups were compared in monocular and binocular qCSF parameters, including the area under logCSF, CSF acuity, and contrast sensitivity (CS) at 1.0-18.0 cycle per degree (cpd).</p><p><strong>Results: </strong>In the monocular comparison, the CSF acuity of the LA group was significantly higher than that of the control group (7.58±5.51 <i>vs</i> 6.37±4.22 cpd, <i>P</i><0.05). The subgroup analysis showed that in the 6-9y group, CSF acuity was significantly higher in the LA group than the control group (8.76±6.19 <i>vs</i> 6.54±4.25 cpd, <i>P</i><0.05), and in the Female group, low refraction sphere group, and high refraction cylinder group, the CS at high spatial frequencies (12.0 and 18.0 cpd) were significantly higher in the LA group than in the control group (all <i>P</i><0.05). In the binocular test, CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group (10.95±7.00 <i>vs</i> 8.65±5.12 cpd; 0.17±0.33 <i>vs</i> 0.06±0.16, respectively; both <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Use of LA may result in improved CS in children with early onset myopia.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 1","pages":"117-124"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672094/pdf/","citationCount":"0","resultStr":"{\"title\":\"Low-concentration atropine (0.01%) on quantitative contrast sensitivity function in Chinese children with myopia.\",\"authors\":\"Yu-Hao Ye, Yi-Yong Xian, Fang Liu, Zhong-Lin Lyu, Xing-Tao Zhou, Jing Zhao\",\"doi\":\"10.18240/ijo.2025.01.14\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To investigate the effect of 0.01% low-concentration atropine (LA) on quantitative contrast sensitivity function (qCSF) in children with myopia.</p><p><strong>Methods: </strong>This paired case-control study included 90 eyes of 58 children who were sex-, age-, and refraction-matched and equally divided into two groups: the 0.01% LA group had undergone 6mo use of daily 0.01% atropine and control group was naïve to LA. Routine ophthalmic examinations and qCSF test without refractive correction were performed. Two groups were compared in monocular and binocular qCSF parameters, including the area under logCSF, CSF acuity, and contrast sensitivity (CS) at 1.0-18.0 cycle per degree (cpd).</p><p><strong>Results: </strong>In the monocular comparison, the CSF acuity of the LA group was significantly higher than that of the control group (7.58±5.51 <i>vs</i> 6.37±4.22 cpd, <i>P</i><0.05). The subgroup analysis showed that in the 6-9y group, CSF acuity was significantly higher in the LA group than the control group (8.76±6.19 <i>vs</i> 6.54±4.25 cpd, <i>P</i><0.05), and in the Female group, low refraction sphere group, and high refraction cylinder group, the CS at high spatial frequencies (12.0 and 18.0 cpd) were significantly higher in the LA group than in the control group (all <i>P</i><0.05). In the binocular test, CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group (10.95±7.00 <i>vs</i> 8.65±5.12 cpd; 0.17±0.33 <i>vs</i> 0.06±0.16, respectively; both <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Use of LA may result in improved CS in children with early onset myopia.</p>\",\"PeriodicalId\":14312,\"journal\":{\"name\":\"International journal of ophthalmology\",\"volume\":\"18 1\",\"pages\":\"117-124\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-01-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672094/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18240/ijo.2025.01.14\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18240/ijo.2025.01.14","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨0.01%低浓度阿托品（LA）对近视儿童定量对比敏感功能（qCSF）的影响。方法：本配对病例对照研究纳入性别、年龄和屈光相匹配的58例儿童90只眼，平均分为两组：0.01% LA组每天使用0.01%阿托品6个月，对照组使用naïve至LA。常规眼科检查及qCSF试验，不做屈光矫正。比较两组单眼和双眼qCSF参数，包括logCSF下面积、CSF敏锐度、对比敏感度（CS） 1.0 ~ 18.0周期/度（cpd）。结果：在单眼比较中，LA组脑脊液敏锐度显著高于对照组(7.58±5.51 vs 6.37±4.22 cpd, ppv 6.54±4.25 cpd, ppv 8.65±5.12 cpd；分别为0.17±0.33 vs 0.06±0.16；结论：使用LA可改善早发性近视儿童的CS。
Low-concentration atropine (0.01%) on quantitative contrast sensitivity function in Chinese children with myopia.
Aim: To investigate the effect of 0.01% low-concentration atropine (LA) on quantitative contrast sensitivity function (qCSF) in children with myopia.
Methods: This paired case-control study included 90 eyes of 58 children who were sex-, age-, and refraction-matched and equally divided into two groups: the 0.01% LA group had undergone 6mo use of daily 0.01% atropine and control group was naïve to LA. Routine ophthalmic examinations and qCSF test without refractive correction were performed. Two groups were compared in monocular and binocular qCSF parameters, including the area under logCSF, CSF acuity, and contrast sensitivity (CS) at 1.0-18.0 cycle per degree (cpd).
Results: In the monocular comparison, the CSF acuity of the LA group was significantly higher than that of the control group (7.58±5.51 vs 6.37±4.22 cpd, P<0.05). The subgroup analysis showed that in the 6-9y group, CSF acuity was significantly higher in the LA group than the control group (8.76±6.19 vs 6.54±4.25 cpd, P<0.05), and in the Female group, low refraction sphere group, and high refraction cylinder group, the CS at high spatial frequencies (12.0 and 18.0 cpd) were significantly higher in the LA group than in the control group (all P<0.05). In the binocular test, CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group (10.95±7.00 vs 8.65±5.12 cpd; 0.17±0.33 vs 0.06±0.16, respectively; both P<0.05).
Conclusion: Use of LA may result in improved CS in children with early onset myopia.
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· International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication
and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online).
This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from
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Chinese Academy of Engineering.
International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of
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Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society).
Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press).
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Prof. Ning-Li Wang (President Elect of APAO);
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Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society);
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