Predictive Value of miR-19-3p and miR-124-3p for Complications and Pelvic Floor Dysfunction in Women Undergoing Cesarean Section.

Complications and pelvic floor dysfunction (PFD) in women after cesarean section have attracted attention. The objective was to identify novel biomarkers that would facilitate more accurate prediction of postpartum complications and PFD, thereby offering new insights into clinical prevention and management strategies. The study population consisted of 120 primigravid women who underwent cesarean section at the hospital. Serum miR-19-3p and miR-124-3p expression was determined by quantitative reverse transcription-polymerase chain reaction. Receiver operating characteristic curves were employed to assess the predictive value of miR-19-3p and miR-124-3p for the occurrence of complications and PFD in women undergoing cesarean section. Multivariate logistic regression was utilized to analyze the risk factors associated with PFD. Fifteen out of 120 women who underwent cesarean section suffered from postpartum complications, and 28 suffered from PFD. miR-19-3p expression was upregulated, and miR-124-3p was downregulated in women presenting with complications and PFD. miR-19-3p and miR-124-3p had a predictive value for both postpartum complications and PFD. miR-19-3p combined with miR-124-3p predicted complications and PFD with an AUC of 0.814 and 0.843, respectively. In addition, miR-19-3p and miR-124-3p were risk factors for PFD in women undergoing cesarean section. In conclusion, the potential exists for the use of miR-19-3p and miR-124-3p as molecular markers to predict postoperative complications and PFD, which may prove beneficial in the management of cesarean section patients.