鼻腔鳞状细胞癌的炎症和营养指标的预后价值：一项单中心回顾性研究。

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY Laryngoscope Investigative Otolaryngology Pub Date : 2025-01-15 DOI:10.1002/lio2.70046

Ce Wu MD, Zhiyu Qi MD, Jiahong Chen MD, Xudong Yan MD, PhD, Shunke Li MD, Lin Wang MD, Longgang Yu MD, PhD, Yan Jiang MD, PhD

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引用次数: 0

摘要

系统性炎症和营养指标与各种癌症的预后相关。然而，它们与鼻窦鳞状细胞癌（SNSCC）预后的关系尚不清楚。本研究旨在确定与SNSCC患者术后预后相关的全身炎症和营养标志物，并阐明这些标志物的临床价值。材料和方法：资料来自129例SNSCC患者。使用曲线下面积确定最佳预后全身性炎症和营养指标。采用COX回归和亚组分析评估预后价值；在这些数据的基础上建立了一个nomogram。结果：晚期肺癌炎症指数（ALI）和全身免疫炎症指数（SII）较其他指标具有较高的预后价值；其临界值分别为27.80和791.35。nomogram包括肿瘤分期、ALI、肿瘤原发部位；校正曲线和决策曲线表明该模型具有较好的临床应用价值。结论：ALI和SII对SNSCC术后患者有潜在的预后价值。本研究所建构的nomogram可作为辅助医师进行临床决策的工具。证据等级：4。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single-center retrospective study

Introduction

Systemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers associated with the postoperative prognosis of patients with SNSCC and to clarify the clinical value of these markers.

Materials and methods

Data from 129 patients with SNSCC were included. The optimal prognostic systemic inflammatory and nutritional markers were identified using the area under the curve. The prognostic value was evaluated using COX regression and subgroup analyses; a nomogram was built based on these data.

Results

The advanced lung cancer inflammation index (ALI) and systemic immune-inflammatory index (SII) had higher prognostic values than the other indices; their cut-off values were 27.80 and 791.35, respectively. The nomogram included tumor stage, ALI, and tumor primary site; the calibration and decision curves indicated that the model had good clinical value.

Conclusion

The ALI and SII have potential prognostic value for postoperative patients with SNSCC. The nomogram constructed in this study could be used as a tool to assist physicians in making clinical decisions.